CAS 666260-75-9

2-[(2,4-Dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(trifluoromethyl)-5-pyrimidinecarboxamide

Description:

The chemical substance known as 2-[(2,4-Dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(trifluoromethyl)-5-pyrimidinecarboxamide, with the CAS number 666260-75-9, is a synthetic organic compound characterized by its complex structure, which includes a pyrimidine ring, a trifluoromethyl group, and a dichlorophenyl moiety. This compound exhibits properties typical of amides, such as potential solubility in polar solvents and the ability to form hydrogen bonds due to the presence of the amide functional group. The presence of the trifluoromethyl group often enhances lipophilicity and biological activity, making it of interest in pharmaceutical research. Additionally, the dichlorophenyl and tetrahydropyran components may contribute to its pharmacokinetic properties and interactions with biological targets. Overall, this compound's unique structural features suggest potential applications in medicinal chemistry, particularly in the development of therapeutic agents. However, specific biological activity and safety profiles would require further investigation through empirical studies.

Formula: C₁₈H₁₇Cl₂F₃N₄O₂

InChI: InChI=1/C18H17Cl2F3N4O2/c19-11-1-2-14(13(20)7-11)26-17-25-9-12(15(27-17)18(21,22)23)16(28)24-8-10-3-5-29-6-4-10/h1-2,7,9-10H,3-6,8H2,(H,24,28)(H,25,26,27)

InChI key: InChIKey=TWQYWUXBZHPIIV-UHFFFAOYSA-N

SMILES: C(NCC1CCOCC1)(=O)C=2C(C(F)(F)F)=NC(NC3=C(Cl)C=C(Cl)C=C3)=NC2

Synonyms:

• 2-(2,4-Dichloroanilino)-N-(oxan-4-ylmethyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide
• 2-(2,4-Dichlorophenylamino)-4-trifluoromethylpyrimidine-5-carboxylic acid [(tetrahydropyran-4-yl)methyl]amide
• 2-[(2,4-Dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(trifluoromethyl)-5-pyrimidinecarboxamide
• 2-[(2,4-dichlorophenyl)amino]-N-(tetrahydro-2H-pyran-4-ylmethyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide
• 5-Pyrimidinecarboxamide, 2-((2,4-dichlorophenyl)amino)-N-((tetrahydro-2H-pyran-4-yl)methyl)-4-(trifluoromethyl)-
• Gw 842166
• Unii-Vl1I6P2Dz8
• GW 842166X
• GW 842166X USP/EP/BP
• GW842166X/GW-842166X
• CS-631
• GW842166X;GW 842166

GW842166X

CAS: 666260-75-9

GW842166X

Purity: ≥98%

Molecular weight: 449.25g/mol

Ref: 54-BUP02963

GW842166X

CAS: 666260-75-9

GW842166X: Potent CB2 agonist, EC50=63 nM, inactive at CB1, in Phase 2 trials.

Formula: C₁₈H₁₇Cl₂F₃N₄O₂

Purity: 99.47%

Color and Shape: Solid

Molecular weight: 449.25

Ref: TM-T6527

GW-842166X

Controlled Product

CAS: 666260-75-9

Applications GW-842166X is pyrimidine ester based compound that is known as a highly selective CB2 receptor agonist for the treatment of inflammatory and neuropathic pain.
References Giblin, G.M.P., et al.: J. Medn. Chem., 50, 2597 (2007)

Formula: C₁₈H₁₇Cl₂F₃N₄O₂

Color and Shape: Neat

Molecular weight: 449.25

Ref: TR-G931520