CAS 66635-92-5

(-)-Ketorolac

Description:

(-)-Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) primarily used for its analgesic properties, particularly in the management of moderate to severe pain. It is characterized by its ability to inhibit the enzyme cyclooxygenase (COX), which plays a crucial role in the synthesis of prostaglandins, compounds involved in inflammation and pain signaling. The substance is typically administered in its racemic form, but the (-)-enantiomer is the more active form. (-)-Ketorolac is known for its potent analgesic effects, often used postoperatively or in acute pain settings. It is available in various formulations, including oral tablets and injectable forms. The drug is generally well-tolerated, but it can have side effects, including gastrointestinal issues, renal impairment, and potential cardiovascular risks, particularly with long-term use. Due to its potency and side effect profile, (-)-Ketorolac is typically recommended for short-term use, and its administration should be carefully monitored by healthcare professionals.

Formula: C₁₅H₁₃NO₃

InChI: InChI=1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)/t11-/m0/s1

InChI key: InChIKey=OZWKMVRBQXNZKK-NSHDSACASA-N

SMILES: C(=O)(C=1N2C([C@@H](C(O)=O)CC2)=CC1)C3=CC=CC=C3

Synonyms:

• 1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro-, (1S)-
• (1S)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
• (S)-Ketorolac
• 1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro-, (S)-
• S-(-)-Ketorolac

(S)-Ketorolac

CAS: 66635-92-5

(S)-Ketorolac is a potent inhibitor of COX1 and COX2 enzyme, and is nonsteroidal anti-inflammatory agent.

Formula: C₁₅H₁₃NO₃

Color and Shape: Solid

Molecular weight: 255.27

Ref: TM-T12802

(S)-Ketorolac

CAS: 66635-92-5

Formula: C₁₅H₁₃NO₃

Molecular weight: 255.27

Ref: 4Z-K-0316

(S)-Ketorolac

Controlled Product

CAS: 66635-92-5

Applications (S)-Ketorolac is the S-enantiomer of Ketorolac. The (S)-enantiomer is about 60 times more potent than (R)-enantiomer. Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory.
References Rooks, W.H., et al.: Agents Actions, 12, 684 (1982), Guzman, A., et al.: J. Med. Chem., 29, 589 (1986), McQuary, H.J., et al.: Clin. Pharmacol. Ther., 39, 89 (1986),

Formula: C₁₅H₁₃NO₃

Color and Shape: Neat

Molecular weight: 255.27

Ref: TR-K235605

Ketorolac S-Isomer

CAS: 66635-92-5

Formula: C₁₅H₁₃NO₃

Molecular weight: 255.27

Ref: ST-EA-CP-K4039