CAS 66635-93-6

(+)-Ketorolac

Description:

(+)-Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) primarily used for its analgesic properties, particularly in the management of moderate to severe pain. It is characterized by its ability to inhibit the enzyme cyclooxygenase (COX), which plays a crucial role in the synthesis of prostaglandins, compounds involved in inflammation and pain signaling. The substance is typically administered in its racemic form, but the (+) enantiomer is the active form that exhibits significant analgesic effects. (+)-Ketorolac is known for its rapid onset of action and is often used in postoperative settings. It is available in various formulations, including oral tablets and injectable forms. The drug is generally well-tolerated, but it can have side effects, including gastrointestinal issues, renal impairment, and potential cardiovascular risks, particularly with long-term use. Due to its potency, it is recommended for short-term use, and its prescribing is often limited to specific clinical scenarios to mitigate risks associated with NSAID therapy.

Formula: C₁₅H₁₃NO₃

InChI: InChI=1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)/t11-/m1/s1

InChI key: InChIKey=OZWKMVRBQXNZKK-LLVKDONJSA-N

SMILES: C(=O)(C=1N2C([C@H](C(O)=O)CC2)=CC1)C3=CC=CC=C3

Synonyms:

• 1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro-, (1R)-
• (1R)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
• (R)-Ketorolac
• 1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro-, (R)-
• R-(+)-Ketorolac

(R)-Ketorolac

CAS: 66635-93-6

(R)-Ketorolac ((+)-Ketorolac) is the R-enantiomer of Ketorolac, with potent analgesic activity.

Formula: C₁₅H₁₃NO₃

Purity: 99.55%

Color and Shape: Solid

Molecular weight: 255.27

Ref: TM-T12624

(R)-Ketorolac

CAS: 66635-93-6

(R)-Ketorolac

Purity: ≥98%

Molecular weight: 255.27g/mol

Ref: 54-BUP04838

(R)-Ketorolac

CAS: 66635-93-6

Formula: C₁₅H₁₃NO₃

Molecular weight: 255.27

Ref: 4Z-K-0315

(R)-Ketorolac

Controlled Product

CAS: 66635-93-6

Applications (R)-Ketorolac is the R-enantiomer of Ketorolac. The (S)-enantiomer is about 60 times more potent than (R)-enantiomer. Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory.
References Rooks, W.H., et al.: Agents Actions, 12, 684 (1982), Guzman, A., et al.: J. Med. Chem., 29, 589 (1986), McQuary, H.J., et al.: Clin. Pharmacol. Ther., 39, 89 (1986),

Formula: C₁₅H₁₃NO₃

Color and Shape: Neat

Molecular weight: 255.27

Ref: TR-K235600

(R)-Ketorolac

CAS: 66635-93-6

Ketorolac is a nonsteroidal anti-inflammatory drug that has been shown to be cytotoxic to human lymphocytes. The mechanism of this cytotoxicity may involve an inhibition of epidermal growth factor receptor, which is an intracellular target for the drug. Ketorolac has also been shown to inhibit the proliferation of mesenchymal cells in culture. Ketorolac has a pharmacologic effect on human serum and can affect women's fertility. These effects are not seen with other nonsteroidal anti-inflammatory drugs. Ketorolac is used as an analytical method for estimating fatty acid levels in biological samples. This drug also reduces the growth of cancer cells and inhibits tumor growth in mice by blocking the production of certain growth factors in the body.

Formula: C₁₅H₁₃NO₃

Purity: 90%Min

Molecular weight: 255.27 g/mol

Ref: 3D-FK24804

Ketorolac R-Isomer

CAS: 66635-93-6

Formula: C₁₅H₁₃NO₃

Molecular weight: 255.27

Ref: ST-EA-CP-K4038