CAS 667-65-2

β-Cortol

Description:

β-Cortol, with the CAS number 667-65-2, is a naturally occurring steroidal compound that is part of the corticoid family. It is characterized by its steroid structure, which typically includes a four-ring carbon framework. β-Cortol is known for its biological activity, particularly in relation to its role in plant physiology and potential applications in medicine. It exhibits anti-inflammatory properties and may influence various metabolic processes. The compound is often studied for its effects on cellular signaling pathways and its potential therapeutic uses. In terms of physical properties, β-Cortol is generally a solid at room temperature and may have low solubility in water, but it is soluble in organic solvents. Its stability and reactivity can vary depending on environmental conditions, such as pH and temperature. Overall, β-Cortol is an important compound in both biological research and potential pharmaceutical applications, warranting further investigation into its mechanisms of action and benefits.

Formula: C₂₁H₃₆O₅

InChI: InChI=1S/C21H36O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12-18,22-26H,3-11H2,1-2H3/t12-,13-,14+,15+,16+,17-,18-,19+,20+,21+/m1/s1

InChI key: InChIKey=FFPUNPBUZDTHJI-ZFOKFBPFSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](O)CC4)[H])([C@@H](O)C1)[H])[H])(CC[C@@]2([C@@H](CO)O)O)[H]

Synonyms:

• (3alpha,5beta,11beta,20R)-pregnane-3,11,17,20,21-pentol
• (3α,5β,11β,20R)-Pregnane-3,11,17,20,21-pentol
• 20β-Cortol
• 3α,11β,17,20β,21-Pentahydroxypregnane
• 5-Beta-Pregnane-3-Alpha,11-Beta,17-Alpha,20-Beta,21-Pentaol
• 5β-Pregnan-3α,11β,20,20β,21-pentol
• 5β-Pregnane-3α,11β,17,20β,21-pentol
• 5β-Pregnane-3α,11β,17α,20β,21-pentol
• Beta-Cortol
• Cortol-20β
• NSC 58792
• Pregnane-3,11,17,20,21-pentol, (3α,5β,11β,20R)-
• Pregnane-3α,11β,17,20β,21-pentol

β-Cortol

Controlled Product

CAS: 667-65-2

Stability Hygroscopic
Applications β-Cortol is a metabolite of cortisol (H714615), a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.
References Pasqualini, J.R., et. al.: J. Eur. Steroids, 1, 63 (1966); Vigore, L., et al.: Cancer Ther., 6, 699 (2008); Puurunen, J., et al.: J. Clin. Endocrinol. Metab., 94, 1973 (2009); Lemos, D., et al.: J. Endocrinol., 201, 275 (2009); Chen, S., et al.: Am. J. Physiol., 296 (2009)

Formula: C₂₁H₃₆O₅

Color and Shape: Neat

Molecular weight: 368.5

Ref: TR-C696295

β-Cortol

Controlled Product

CAS: 667-65-2

Cortol is a drug that is used to treat cancer. It binds to the mineralocorticoid receptor, which is an intracellular protein that regulates the production of glucocorticoids and other hormones. Cortol has been shown to inhibit oxidative DNA damage in urine samples from women with breast cancer. Cortol may also have an inhibitory effect on insulin sensitivity in women. Cortol binds to the estrogen receptor on cells and inhibits the expression of genes encoding enzymes involved in lipid metabolism. It also inhibits growth factor activity, which can lead to inhibition of ovary cell proliferation and increased body mass index in women. Cortol has been shown to improve insulin resistance by increasing glucose uptake and reducing hepatic glucose output in animal models.

Formula: C₂₁H₃₆O₅

Purity: Min. 95%

Molecular weight: 368.5 g/mol

Ref: 3D-AAA66765

β-Cortol

CAS: 667-65-2

Beta-Cortol is a metabolite of androgen present in adults.

Formula: C₂₁H₃₆O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 368.51

Ref: TM-T13575