CAS 667-66-3

β-Cortolone

Description:

β-Cortolone, with the CAS number 667-66-3, is a steroid hormone that belongs to the class of corticosteroids. It is a derivative of cortisol and is characterized by its four-ring core structure typical of steroids. β-Cortolone exhibits anti-inflammatory and immunosuppressive properties, making it relevant in medical applications, particularly in the treatment of various inflammatory conditions. The compound is typically found in a crystalline form and is soluble in organic solvents but has limited solubility in water. Its molecular structure includes functional groups that contribute to its biological activity, including a ketone and hydroxyl groups. β-Cortolone can be synthesized through various chemical pathways, often involving the oxidation of cortisol or related compounds. In terms of safety, like many corticosteroids, it should be handled with care, as it can have significant physiological effects and potential side effects when used therapeutically. Overall, β-Cortolone plays a crucial role in pharmacology and biochemistry, particularly in the context of hormone regulation and therapeutic interventions.

Formula: C₂₁H₃₄O₅

InChI: InChI=1/C21H34O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12-15,17-18,22-23,25-26H,3-11H2,1-2H3/t12-,13-,14+,15+,17-,18-,19+,20+,21+/m1/s1

InChI key: InChIKey=JXCOSKURGJMQSG-AIEJOZITSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](O)CC4)[H])(C(=O)C1)[H])[H])(CC[C@@]2([C@@H](CO)O)O)[H]

Synonyms:

• (3alpha,5beta,20R)-3,17,20,21-tetrahydroxypregnan-11-one
• (3α,5β,20R)-3,17,20,21-Tetrahydroxypregnan-11-one
• 11-Pregnanone, 3α,17,20β,21-tetrahydroxy-
• 20β-Cortolone
• 20β-Hexahydrocortisone
• 3-Alpha,17-Alpha,20-Beta,21-Tetrahydroxy-5-Beta-Pregnan-11-One
• 3α,17,20β,21-Tetrahydroxy-5β-pregnan-11-one
• 3α,17α,20β,21-Tetrahydroxy-5β-pregnan-11-one
• 5β-Pregnan-11-one, 3α,17,20β,21-tetrahydroxy-
• 5β-Pregnan-3α,17α,20β,21-tetrol-11-one
• 5β-Pregnane-3α,17α,20β,21-tetrol-11-one
• NSC 56997
• Pregnan-11-one, 3,17,20,21-tetrahydroxy-, (3α,5β,20R)-
• β-Cortolone
• β-Cortolone D5
• (20R)-3α,17α,20,21-Tetrahydroxy-5β-pregnan-11-one
• 2-Cortolone
• (3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-3,17-dihydr oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopen ta[a]phenanthren-11-one

b-Cortolone

CAS: 667-66-3

b-Cortolone, a metabolite of Cortisol, exhibits relatively lower biological activity.

Formula: C₂₁H₃₄O₅

Color and Shape: Solid

Molecular weight: 366.49

Ref: TM-T203099

β-Cortolone

Controlled Product

CAS: 667-66-3

Applications β-Cortolone is a metabolite of Cortisol (H714615), a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.
References Fukushima, D.K., et. al.: Steroids, 35, 209 (1980); Vigore, L., et al.: Cancer Ther., 6, 699 (2008); Puurunen, J., et al.: J. Clin. Endocrinol. Metab., 94, 1973 (2009); Lemos, D., et al.: J. Endocrinol., 201, 275 (2009); Chen, S., et al.: Am. J. Physiol., 296 (2009)

Formula: C₂₁H₃₄O₅

Color and Shape: Off-White

Molecular weight: 366.49

Ref: TR-C696285

β-Cortolone

Controlled Product

CAS: 667-66-3

β-Cortolone is a synthetic drug that is used to treat high blood pressure. It has been shown to reduce the risk of death from cancer in women, and may be a potential biomarker for bladder cancer. β-Cortolone binds with high affinity to corticosteroid receptors, which are expressed in many different tissues. This binding can lead to the release of inflammatory mediators and has been linked to increased risk of cardiovascular disease, osteoporosis, and diabetes. β-Cortolone may also have metabolic effects on the kidneys, liver, or brain cells.

Formula: C₂₁H₃₄O₅

Purity: Min. 95%

Molecular weight: 366.5 g/mol

Ref: 3D-AAA66766