CAS 66701-25-5

trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane

Description:

Trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane, identified by its CAS number 66701-25-5, is a synthetic compound that exhibits characteristics typical of peptide-like structures. This substance features an epoxide functional group, which contributes to its reactivity, particularly in biological systems where it may interact with nucleophiles. The presence of a guanidino group suggests potential biological activity, as guanidino compounds are often involved in enzyme inhibition or modulation. The L-leucylamido component indicates that it is derived from the amino acid leucine, which may influence its interaction with biological receptors or enzymes. Additionally, the overall structure suggests that it may possess properties relevant to medicinal chemistry, particularly in the development of therapeutic agents targeting specific biological pathways. Its stability, solubility, and reactivity would depend on the surrounding conditions, such as pH and temperature, making it a compound of interest for further research in pharmacology and biochemistry.

Formula: C₁₅H₂₇N₅O₅

InChI: InChI=1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10-,11-/m0/s1

InChI key: InChIKey=LTLYEAJONXGNFG-DCAQKATOSA-N

SMILES: C(N[C@H](C(NCCCCNC(=N)N)=O)CC(C)C)(=O)[C@@H]1[C@@H](C(O)=O)O1

Synonyms:

• (2R,3R)-3-{[(2S)-1-({4-[(diaminomethylidene)amino]butyl}amino)-4-methyl-1-oxopentan-2-yl]carbamoyl}oxirane-2-carboxylic acid
• (2S,3S)-3-[[[(1S)-1-[[[4-[(Aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-2-oxiranecarboxylic acid
• (2S,3S)-3-{[(2S)-1-({4-[(diaminomethylidene)amino]butyl}amino)-4-methyl-1-oxopentan-2-yl]carbamoyl}oxirane-2-carboxylic acid
• 2-Oxiranecarboxylic acid, 3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-, (2S,3S)-
• E 64 (proteinase inhibitor)
• E-64
• E-64 Protease Inhibitor
• E64
• Oxiranecarboxylic acid, 3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-, (2S,3S)-
• Oxiranecarboxylic acid, 3-[[[1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-, [2S-[2α,3β(R*)]]-
• Proteinase inhibitor E 64
• trans-Epoxysuccinyl-<span class="text-smallcaps">L</span>-leucylamido-(4-guanidino)butane
• trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane

E-64

CAS: 66701-25-5

Selective and irreversible cysteine protease inhibitor

Formula: C₁₅H₂₇N₅O₅

Color and Shape: White to pale cream, Crystals or powder or crystalline powder

Molecular weight: 357.4

Ref: 02-J62933

L-trans-Epoxysuccinyl-Leu-4-guanidinobutylamide

CAS: 66701-25-5

Most commonly used diagnostic inhibitor for the characterization of cysteine proteinases. Originally isolated from cultures of Aspergillus japonicus, E64 is a non-competitive, irreversible inhibitor of thiol proteinases of the papain and calpain families.

Formula: C₁₅H₂₇N₅O₅

Purity: 99.7%

Molecular weight: 357.41

Ref: 01-4027910

E-64

CAS: 66701-25-5

Formula: C₁₅H₂₇N₅O₅

Purity: 99%

Color and Shape: Solid

Molecular weight: 357.4054

Ref: IN-DA0036TL

E-64

CAS: 66701-25-5

E-64

Purity: ≥98%

Molecular weight: 357.41g/mol

Ref: 54-BUP13066

E-64

CAS: 66701-25-5

E-64

Formula: C₁₅H₂₇N₅O₅

Purity: 95%

Color and Shape: white to off-white powder

Molecular weight: 357.41g/mol

Ref: 54-BIMI2157

E-64 protease inhibitor

CAS: 66701-25-5

Formula: C₁₅H₂₇N₅O₅

Purity: (HPLC) ≥ 98.0%

Color and Shape: White crystalline powder

Molecular weight: 357.40

Ref: 7W-GL4130

E-64

CAS: 66701-25-5

Formula: C₁₅H₂₇N₅O₅

Molecular weight: 357.41

Ref: 4Z-E-189001

E-64

CAS: 66701-25-5

E-64 (Proteinase inhibitor E 64) is an irreversible and specific cysteine protease inhibitor. The IC50 of E-64 for papain is 9 nM.

Formula: C₁₅H₂₇N₅O₅

Purity: 98% - 99.95%

Color and Shape: White Solid

Molecular weight: 357.41

Ref: TM-T6037

E 64

Controlled Product

CAS: 66701-25-5

Formula: C₁₅H₂₇N₅O₅

Color and Shape: Neat

Molecular weight: 357.41

Ref: TR-E100490

E-64

CAS: 66701-25-5

Inhibitor of cathepsins and other cysteine proteases

Formula: C₁₅H₂₇N₅O₅

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 357.41 g/mol

Ref: 3D-FE29621

E-64

CAS: 66701-25-5

E-64 is a chemical inhibitor that binds to the ATP synthase in mitochondria, inhibiting oxidative phosphorylation. This inhibition of mitochondrial energy production leads to cell death by apoptosis. E-64 has been shown to inhibit tumor growth in vitro and in vivo by inducing autophagy and inhibiting cancer cell proliferation. E-64 has also been shown to have proteolytic activity against serum proteins, which may be due to its ability to bind to the phosphate groups of proteins.

Formula: C₁₅H₂₇N₅O₅H₂O

Purity: Min. 95%

Molecular weight: 366.42 g/mol

Ref: 3D-IES-4096

E 64-d8

Controlled Product

CAS: 66701-25-5

Formula: C₁₅D₈H₁₉N₅O₅

Color and Shape: Neat

Molecular weight: 365.455

Ref: TR-E100492

E-64

CAS: 66701-25-5

E-64 is a research tool that is used to study protein interactions. It has been shown to inhibit ion channels, such as the nicotinic acetylcholine receptor and the voltage-gated calcium channel. E-64 binds to receptors in the cell membrane, blocking ion channels and altering intracellular signaling pathways. E-64 has been shown to inhibit nitric oxide synthase, which may account for its anti-inflammatory properties. E-64 also inhibits an enzyme called protein tyrosine phosphatase 1B (PTP1B), which is involved in insulin resistance and type 2 diabetes mellitus.

Formula: C₁₅H₂₇N₅O₅

Purity: Min. 95%

Molecular weight: 357.41 g/mol

Ref: 3D-IES-4096-V