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CAS 66711-21-5

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Apraclonidine

Description:
Apraclonidine is a selective alpha-2 adrenergic agonist primarily used in ophthalmology to lower intraocular pressure in conditions such as glaucoma. It is characterized by its ability to reduce aqueous humor production and increase uveoscleral outflow, thereby decreasing intraocular pressure. The substance is typically administered as an eye drop solution. Apraclonidine has a relatively short duration of action and is often used in conjunction with other medications for enhanced efficacy. Its chemical structure includes a substituted imidazoline ring, which is crucial for its pharmacological activity. Common side effects may include ocular irritation, dry mouth, and fatigue, reflecting its systemic absorption and central nervous system effects. Apraclonidine is also notable for its potential to cause tachyphylaxis, where its effectiveness diminishes with prolonged use. As with any medication, it is essential to consider contraindications and interactions with other drugs when prescribing apraclonidine.
Formula:C9H10Cl2N4
InChI:InChI=1S/C9H10Cl2N4/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9/h3-4H,1-2,12H2,(H2,13,14,15)
InChI key:InChIKey=IEJXVRYNEISIKR-UHFFFAOYSA-N
SMILES:N(C1=C(Cl)C=C(N)C=C1Cl)C=2NCCN2
Synonyms:
  • 1,4-Benzenediamine, 2,6-dichloro-N<sup>1</sup>-(4,5-dihydro-1H-imidazol-2-yl)-
  • 2,6-Dichloro-N1-(2-imidazolidinylidene)-1,4-benzenediamine
  • 2,6-Dichloro-N<sup>1</sup>-(4,5-dihydro-1H-imidazol-2-yl)-1,4-benzenediamine
  • 2,6-dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine
  • 2-(4-Amino-2,6-dichlorophenylamino)-2-imidazoline
  • Aplonidine
  • Apraclonidine
  • Lopidine
  • Nc 14
  • 2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)-1,4-benzenediamine
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