CAS 667463-62-9

6-Bromoindirubin-3′-oxime

Description:

6-Bromoindirubin-3′-oxime is a synthetic organic compound that belongs to the class of indirubins, which are known for their diverse biological activities. This compound features a bromine atom at the 6-position of the indirubin structure and an oxime functional group at the 3′ position, contributing to its unique chemical properties. It is characterized by its potential as a kinase inhibitor, particularly in the context of cancer research, where it may influence cell proliferation and apoptosis. The compound typically exhibits moderate solubility in organic solvents and may have limited solubility in water, which is common for many organic compounds. Its molecular structure allows for interactions with various biological targets, making it a subject of interest in medicinal chemistry. Additionally, 6-Bromoindirubin-3′-oxime may undergo various chemical reactions, including oxidation and substitution, which can be exploited in synthetic applications. Safety and handling precautions should be observed due to its potential biological activity and the presence of bromine, which can be hazardous.

Formula: C₁₆H₁₀BrN₃O₂

InChI: InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,18,22H,(H,19,21)/b15-13-,20-14+

InChI key: InChIKey=DDLZLOKCJHBUHD-WAVHTBQISA-N

SMILES: O=C1\C(\C=2C(N1)=CC(Br)=CC2)=C/3\C(=N\O)\C=4C(N3)=CC=CC4

Synonyms:

• (3Z)-6-Bromo-3-[(3E)-1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
• (2′Z,3′E)-6-Bromoindirubin-3′-oxime
• 2H-Indol-2-one, 6-bromo-3-[(3E)-1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-, (3Z)-
• GSK 3 IX
• GSK 3 Inhibitor IX

(2'Z,3'E)-6-Bromoindirubin-3'-oxime

CAS: 667463-62-9

Formula: C₁₆H₁₀BrN₃O₂

Purity: >95.0%(HPLC)

Color and Shape: Orange to Amber to Dark red powder to crystal

Molecular weight: 356.18

Ref: 3B-B4006

6-Bromoindirubin-3'-oxime, 97%

CAS: 667463-62-9

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₁₆H₁₀BrN₃O₂

Purity: 97%

Color and Shape: Solid, Pink to red to dark red

Molecular weight: 356.18

Ref: 02-J67275

BIO

CAS: 667463-62-9

Formula: C₁₆H₁₀BrN₃O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 356.1735

Ref: IN-DA00FBIC

GSK 3 Inhibitor IX

CAS: 667463-62-9

GSK 3 Inhibitor IX

Purity: ≥98%

Molecular weight: 356.17g/mol

Ref: 54-BUP12092

(2Z,3E)-6'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one

CAS: 667463-62-9

(2Z,3E)-6'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one

Purity: 99%

Molecular weight: 356.17g/mol

Ref: 54-OR1025502

BIO

CAS: 667463-62-9

Formula: C₁₆H₁₀BrN₃O₂

Molecular weight: 356.17

Ref: 7W-GL6265

GSK 3 Inhibitor IX

CAS: 667463-62-9

GSK 3 Inhibitor IX (6-BIO) is a selective reversible, ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex.

Formula: C₁₆H₁₀BrN₃O₂

Purity: 98% - 99.72%

Color and Shape: Solid

Molecular weight: 356.17

Ref: TM-T1917

BIO

CAS: 667463-62-9

Specific inhibitor of glycogen synthase kinase 3 (GSK-3) with IC50 in low nanomolar range. Studies showed that BIO maintains self-renewal in embryonic stem cells (ESCs) as well as increases activity of β-catenin. In neonatal cardiomyocytes, BIO promotes cell cycle by stimulating cell entry into S phase as well as cytokinesis. In germline stem cells from female mice (FGSCs), BIO promoted proliferation and maintenance of FGSCs by activating β-catenin and up-regulating E-cadherin.

Formula: C₁₆H₁₀BrN₃O₂

Purity: Min. 95%

Color and Shape: Red To Dark Red Solid

Molecular weight: 356.17 g/mol

Ref: 3D-BB162775

(2Z,3E)-6′-BROMO-3-(HYDROXYIMINO)-[2,3′-BIINDOLINYLIDENE]-2′-ONE

CAS: 667463-62-9

Formula: C₁₆H₁₀BrN₃O₂

Purity: 98%

Molecular weight: 356.179

Ref: 10-F538211