CAS 6677-99-2

Hydrocortisone-21-butyrate

Description:

Hydrocortisone-21-butyrate is a synthetic corticosteroid derived from hydrocortisone, primarily used for its anti-inflammatory and immunosuppressive properties. It is characterized by its butyrate ester modification at the 21-position, which enhances its potency and reduces systemic side effects compared to other corticosteroids. This compound is typically utilized in dermatological formulations for the treatment of various skin conditions, including eczema, dermatitis, and psoriasis, due to its ability to reduce inflammation and itching. Hydrocortisone-21-butyrate exhibits a favorable pharmacokinetic profile, allowing for effective topical application with minimal systemic absorption. Its mechanism of action involves the modulation of gene expression related to inflammatory processes, leading to decreased production of pro-inflammatory cytokines. As with other corticosteroids, prolonged use may lead to potential side effects, including skin atrophy and local irritation. Therefore, it is essential to use this medication under medical supervision, adhering to prescribed dosages and treatment durations to minimize adverse effects while maximizing therapeutic benefits.

Formula: C₂₅H₃₆O₆

InChI: InChI=1S/C25H36O6/c1-4-5-21(29)31-14-20(28)25(30)11-9-18-17-7-6-15-12-16(26)8-10-23(15,2)22(17)19(27)13-24(18,25)3/h12,17-19,22,27,30H,4-11,13-14H2,1-3H3/t17-,18-,19-,22+,23-,24-,25-/m0/s1

InChI key: InChIKey=YZNQMPPBWQTLFJ-TUFAYURCSA-N

SMILES: C[C@@]12[C@]([C@]3([C@]([C@@H](O)C1)([C@]4(C)C(CC3)=CC(=O)CC4)[H])[H])(CC[C@@]2(C(COC(CCC)=O)=O)O)[H]

Synonyms:

• (11Beta)-11,17-Dihydroxy-3,20-Dioxopregn-4-En-21-Yl Butanoate
• (11β)-11,17-Dihydroxy-21-(1-oxobutoxy)pregn-4-ene-3,20-dione
• 11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 21-butyrate
• Ceneo
• Cortisol, 21-butyrate
• HB(sub 21)
• Hydrocortisone 21-butyrate
• Isdinium
• Pregn-4-en-3,20-dione, 11,17-dihydroxy-21-(1-oxobutoxy)-, (11-beta)- (9CI)
• Pregn-4-ene-3,20-dione, 11,17-dihydroxy-21-(1-oxobutoxy)-, (11β)-
• Stero To

Hydrocortisone 21-Butyrate (11β,17-Dihydroxy-3,20-dioxopregna-4-en-21-yl butyrate)

CAS: 6677-99-2

Carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides etc, nesoi

Formula: C₂₅H₃₆O₆

Molecular weight: 432.25119

Ref: 45-1A13320

Hydrocortisone 21-Butyrate

CAS: 6677-99-2

Color and Shape: Neat

Ref: 86-MM0188.01

Hydrocortisone 21-Butyrate

Controlled Product

CAS: 6677-99-2

Applications Glucocorticoid.
References Middleton, B., et al.: J. Biol. Chem., 256, 4827 (1981), Moore, A., et al.: Ann. Clin. Biochem., 22, 435 (1985).

Formula: C₂₅H₃₆O₆

Color and Shape: White

Molecular weight: 432.55

Ref: TR-H714625

Hydrocortisone 21-butyrate

Controlled Product

CAS: 6677-99-2

Hydrocortisone 21-butyrate is a synthetic corticosteroid with potent anti-inflammatory, immunosuppressive and antipruritic properties. It is a prodrug of hydrocortisone, which is converted to the active form in the body. Hydrocortisone 21-butyrate binds to the glucocorticoid receptor protein in the cytosol and has been shown to be effective for the treatment of cutaneous tissue inflammation in humans. The drug's affinity for the glucocorticoid receptor is increased by high lipophilicity and decreased by low lipophilicity. Clinical data shows that steady-state concentrations are reached after 3 days of use, suggesting that it has a long half-life.

Formula: C₂₅H₃₆O₆

Purity: Min. 95%

Molecular weight: 432.55 g/mol

Ref: 3D-FH23888

Hydrocortisone-21-Butyrate

CAS: 6677-99-2

Formula: C₂₅H₃₆O₆

Molecular weight: 432.56

Ref: ST-EA-CP-H9019