CAS 6678-00-8
:Hydrocortisone 21-valerate
Description:
Hydrocortisone 21-valerate is a synthetic corticosteroid derivative of hydrocortisone, primarily used for its anti-inflammatory and immunosuppressive properties. It is characterized by the addition of a valerate ester group at the 21 position of the hydrocortisone molecule, which enhances its potency and duration of action compared to hydrocortisone itself. This compound is typically administered topically in formulations for treating various skin conditions, such as eczema and dermatitis, due to its ability to reduce inflammation and alleviate itching. Hydrocortisone 21-valerate exhibits a favorable pharmacokinetic profile, allowing for effective local action with minimal systemic absorption when applied to the skin. Its chemical structure contributes to its solubility and stability, making it suitable for pharmaceutical preparations. As with other corticosteroids, potential side effects may include skin thinning and local irritation, necessitating careful monitoring during use. Overall, hydrocortisone 21-valerate is a valuable therapeutic agent in dermatology, providing effective relief for inflammatory skin disorders.
Formula:C26H38O6
InChI:InChI=1/C26H38O6/c1-4-5-6-22(30)32-15-21(29)26(31)12-10-19-18-8-7-16-13-17(27)9-11-24(16,2)23(18)20(28)14-25(19,26)3/h13,18-20,23,28,31H,4-12,14-15H2,1-3H3/t18-,19-,20-,23+,24-,25-,26-/m0/s1
InChI key:InChIKey=XHDMDWMKAYYIRK-FZNHGJLXSA-N
SMILES:C[C@@]12[C@]([C@]3([C@]([C@@H](O)C1)([C@]4(C)C(CC3)=CC(=O)CC4)[H])[H])(CC[C@@]2(C(COC(CCCC)=O)=O)O)[H]
Synonyms:- (11Beta)-11,17-Dihydroxy-3,20-Dioxopregn-4-En-21-Yl Pentanoate
- (11β)-11,17-Dihydroxy-21-[(1-oxopentyl)oxy]pregn-4-ene-3,20-dione
- 11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 21-valerate
- Cortisol, 21-valerate
- Hydrocortisone 21-valerate
- Pregn-4-ene-3,20-dione, 11,17-dihydroxy-21-[(1-oxopentyl)oxy]-, (11β)-
- Hydrocortisone Impurity 49
- Valeric acid 11β,17-dihydroxy-3,20-dioxopregn-4-en-21-yl ester
- XHDMDWMKAYYIRK-FZNHGJLXSA-N
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Found 5 products.
Hydrocortisone 21-Valerate
CAS:Controlled ProductApplications Hydrocortisone 21-Valerate is a derivative of Hydrocortisone (H714615) a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.
References O'Neill, R. et al.: J. Pharm. Pharmacol., 32, (1980); Vigore, L., et al.: Cancer Ther., 6, 699 (2008), Puurunen, J., et al.: J. Clin. Endocrinol. Metab., 94, 1973 (2009), Lemos, D., et al.: J. Endocrinol., 201, 275 (2009), Chen, S., et al.: Am. J. Physiol., 296 (2009),Formula:C26H38O6Color and Shape:NeatMolecular weight:446.58Hydrocortisone 21-valerate
CAS:Controlled ProductHydrocortisone 21-valerate is a synthetic corticosteroid with anti-inflammatory properties. Hydrocortisone 21-valerate is water soluble and can be used in solutions for injection or topical applications. It is an ester of hydrocortisone and valeric acid. Hydrocortisone 21-valerate is also known as valerianate hydrocortisone, hydrocortisone acetate, or hydrocortisonum valerianate. Hydrocortisone 21-valerate has been shown to be effective in treating the symptoms of allergic reactions, eczema, and seborrhea when applied topically. This drug has a molecular weight of 418.5 and is an homologous series of hexane, acetonitrile, and water. The systematic name for this molecule is 9alpha,11beta,16alpha-trihydroxypregna-1,4-diene-Formula:C26H38O6Purity:Min. 95%Molecular weight:446.6 g/mol
