CAS 667882-55-5

Uridine 5'-(tetrahydrogen triphosphate), 4'-thio-, trisodium salt

Formula: C₉H₁₅N₂O₁₄P₃SNa

Nsp12-IN-2

CAS: 667882-55-5

Nsp12-IN-2 (Compound 8), a triphosphate metabolite of 4'-thiouridine, functions as an inhibitor of SARS-CoV-2 Nsp12. It effectively suppresses the RNA-dependent RNA polymerase (RdRp) activity of the SARS-CoV-2 Nsp12-Nsp7-Nsp8 complex, halting RNA synthesis and blocking the RNA capping and NMP capping of Nsp9. Nsp12-IN-2 shows potential for research into infections caused by SARS-CoV-2, other coronaviruses, and additional RNA viruses.

Formula: C₉H₁₂N₂Na₃O₁₄P₃S

Color and Shape: Solid

Molecular weight: 566.15

Ref: TM-T211588