CAS 66803-19-8

Micronomicin sulfate

Description:

Micronomicin sulfate is an aminoglycoside antibiotic derived from Micromonospora purpurea, primarily used for its antibacterial properties. It exhibits a broad spectrum of activity against various Gram-negative and some Gram-positive bacteria, making it effective in treating infections, particularly those caused by resistant strains. The compound functions by inhibiting bacterial protein synthesis, which is crucial for bacterial growth and replication. Micronomicin sulfate is typically administered via injection and is known for its relatively low toxicity compared to other aminoglycosides, although it can still pose risks such as nephrotoxicity and ototoxicity. The sulfate form enhances its solubility and stability in solution, facilitating its use in clinical settings. As with other aminoglycosides, careful monitoring of drug levels in the bloodstream is essential to avoid adverse effects. Overall, Micronomicin sulfate is a valuable antibiotic in the therapeutic arsenal against bacterial infections, particularly in cases where other treatments may fail due to resistance.

Formula: C₂₀H₄₃N₅O₁₁S

InChI: InChI=1/C20H41N5O7.H2O4S/c1-20(28)8-29-19(14(27)17(20)25-3)32-16-12(23)6-11(22)15(13(16)26)31-18-10(21)5-4-9(30-18)7-24-2;1-5(2,3)4/h9-19,24-28H,4-8,21-23H2,1-3H3;(H2,1,2,3,4)/t9-,10+,11-,12+,13-,14+,15+,16-,17+,18+,19+,20-;/m0./s1

InChI key: InChIKey=MQDGQSCLOYLSEK-SCFBDNQUSA-N

SMILES: O([C@@H]1[C@@H](O)[C@H](O[C@H]2O[C@H](CNC)CC[C@H]2N)[C@@H](N)C[C@H]1N)[C@@H]3[C@H](O)[C@@H](NC)[C@@](C)(O)CO3.S(=O)(=O)(O)O

Synonyms:

• (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2-amino-2,3,4,6-tetradeoxy-6-(methylamino)-alpha-D-erythro-hexopyranoside sulfate (1:1)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2-amino-2,3,4,6-tetradeoxy-6-(methylamino)-α-<smallcap>D</smallcap>-erythro-hexopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-<smallcap>L</span>-arabinopyranosyl-(1→6)]-2-deoxy-, sulfate (1:?)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2-amino-2,3,4,6-tetradeoxy-6-(methylamino)-α-<smallcap>D</smallcap>-erythro-hexopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-<smallcap>L</span>-arabinopyranosyl-(1→6)]-2-deoxy-, sulfate (salt)
• Micronomycin sulfate
• Streptamine, O-2-amino-2,3,4,6-tetradeoxy-6-(methylamino)-alpha-D-erythro-hexopyranosyl-(1-4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6))-2-deoxy-, sulfate, D-
• Micronomicin sulfate
• D-Streptamine, O-2-amino-2,3,4,6-tetradeoxy-6-(methylamino)-α-D-erythro-hexopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-2-deoxy-, sulfate (1:?)
• D-Streptamine, O-2-amino-2,3,4,6-tetradeoxy-6-(methylamino)-α-D-erythro-hexopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-2-deoxy-, sulfate (salt)
• yranosyl-(1-4)-o-(3-deoxy-4-c-methyl-3-(methylamino)-beta-l-arabinopyranosyl-(
• MICRONOMICIN SULFATE USP/EP/BP
• streptamine,o-2-amino-2,3,4,6-tetradeoxy-6-(methylamino)-alpha-d-erythro-hexop
• sulfate,d-1-6))-2-deoxy
• (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,6S)-3-amino-6-(methylaminomethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol,sulfuric acid
• D-Streptamine, O-2-amino-2,3,4,6-tetradeoxy-6-(methylamino)-a-D-erythro-hexopyranosyl-(14)-O-[3-deoxy-4-C-methyl-3-(methylamino)-b-L-arabinopyranosyl-(16)]-2-deoxy-, sulfate (salt) (9CI)
• 6'-N-METHYLGENTAMICIN C1A HEMIPENTASULFATE
• Micronomicin sulfate JAS1998
• Micronomicin Sulfate CAS: 66803-19-8

Micronomicin sulfate, 590 ^mg/mg

CAS: 66803-19-8

An aminoglycoside antibiotic commonly used against Gram-negative bacteria This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU

Formula: C₂₀H₄₁N₅O₇•H₂SO₄

Color and Shape: White to off-white, Powder

Molecular weight: 561.65

Ref: 02-J66072

(2R,3R,4R,5R)-2-(((1S,2S,3R,4S,6R)-4,6-Diamino-3-(((2R,3R,6S)-3-amino-6-((methylamino)methyl)tetrahydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)-5-methyl-4-(methylamino)tetrahydro-2H-pyran-3,5-diol sulfate

CAS: 66803-19-8

Formula: C₂₀H₄₃N₅O₁₁S

Purity: 95%

Color and Shape: Solid

Molecular weight: 561.6473

Ref: IN-DA00FA9E

Micronomicin sulfate

CAS: 66803-19-8

Micronomicin sulfate

Purity: ≥95%

Ref: 54-BUP20960

Micronomicin sulfate

CAS: 66803-19-8

Micronomicin sulfate (Gentamicin C2b sulfate) is an aminoglycoside antibiotic with antimicrobial activity that inhibits neuraminidase N1 of influenza A virus.

Formula: C₂₀H₄₁N₅O₇xH₂O₄S

Color and Shape: Solid

Molecular weight: #VALUE!

Ref: TM-T41294

Micronomicin Sulfate (~80%)

Controlled Product

CAS: 66803-19-8

Applications Micronomicin Sulfate is an aminoglycoside antibiotic with neuromuscular blocking activity.
References Matsukawa, S., et al.: Tohoku J. Exp. Med., 181, 471 (1997)

Formula: C₂₀H₄₁N₅O₇·H₂O₄S

Purity: ~80%

Color and Shape: Neat

Molecular weight: 561.65

Ref: TR-M342900

Micronomicin Sulfate

CAS: 66803-19-8

Micronomicin sulfate is an antimicrobial agent that belongs to the group of sulfonamides. It has been used in clinical studies for the treatment of chronic bronchitis. Micronomicin sulfate inhibits bacterial growth by binding to fatty acid synthesis enzymes and inhibiting membrane function. This drug also has a broad-spectrum antimicrobial action, which includes activity against gram-positive bacteria, gram-negative bacteria, and fungi. Micronomicin sulfate is not active against mycobacteria and is used in combination with other antibiotics for the treatment of infections caused by these bacteria. Micronomicin sulfate can be administered intravenously as an injection solution or orally as a tablet or syrup. It can also be given rectally as an enema solution or suppository. A formulation for intramuscular injection is also available but this formulation should not be injected into a vein or artery.

Formula: C₂₀H₄₁N₅O₇xH₂SO₄

Purity: Min. 590 Ug/Mg

Color and Shape: Powder

Molecular weight: 463.57 g/mol

Ref: 3D-RCA80319