CAS 668270-12-0

Linagliptin

Description:

Linagliptin is an oral antihyperglycemic agent primarily used in the management of type 2 diabetes mellitus. It belongs to the class of medications known as DPP-4 inhibitors, which work by increasing incretin levels, thereby enhancing insulin secretion and decreasing glucagon levels in a glucose-dependent manner. This mechanism helps to lower blood glucose levels without causing significant hypoglycemia. Linagliptin is characterized by its high selectivity for the DPP-4 enzyme, which contributes to its efficacy and safety profile. The substance is typically administered once daily due to its long half-life, allowing for convenient dosing. Linagliptin is also notable for its minimal renal excretion, making it suitable for patients with renal impairment. In terms of chemical properties, it has a molecular formula that reflects its complex structure, which includes multiple functional groups that contribute to its pharmacological activity. Overall, Linagliptin is recognized for its effectiveness in glycemic control and its favorable tolerability profile in diabetic patients.

Formula: C₂₅H₂₈N₈O₂

InChI: InChI=1S/C25H28N8O2/c1-4-5-13-32-21-22(29-24(32)31-12-8-9-17(26)14-31)30(3)25(35)33(23(21)34)15-20-27-16(2)18-10-6-7-11-19(18)28-20/h6-7,10-11,17H,8-9,12-15,26H2,1-3H3/t17-/m1/s1

InChI key: InChIKey=LTXREWYXXSTFRX-QGZVFWFLSA-N

SMILES: C(C#CC)N1C2=C(N=C1N3C[C@H](N)CCC3)N(C)C(=O)N(CC4=NC5=C(C(C)=N4)C=CC=C5)C2=O

Synonyms:

• (R)-8-[3-Aminopiperidin-1-yl]-7-(2-butynyl)-3-methyl-1-(4-methylquinazolin-2-ylmethyl)xanthine
• 1H-Purine-2,6-Dione, 8-[(3R)-3-Amino-1-Piperidinyl]-7-(2-Butyn-1-Yl)-3,7-Dihydro-3-Methyl-1-[(4-Methyl-2-Quinazolinyl)Methyl]-
• 1H-Purine-2,6-dione, 8-[(3R)-3-amino-1-piperidinyl]-7-(2-butynyl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-
• 8-[(3R)-3-Amino-1-piperidinyl]-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione
• 8-[(3R)-3-Amino-1-piperidinyl]-7-(2-butynyl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione
• 8-[(3R)-3-aminopiperidin-1-yl]-7-(but-2-yn-1-yl)-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-dione
• Bi 1356
• Bi 1356Bs
• Ondero
• Tradjenta
• Trajenta

Linagliptin

CAS: 668270-12-0

Color and Shape: Neat

Ref: 61-FOR3412.00

Linagliptin

CAS: 668270-12-0

Linagliptin (BI 1356) is a potent, orally bioavailable dihydropurinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.

Formula: C₂₅H₂₈N₈O₂

Purity: 99.15% - >99.99%

Color and Shape: Solid

Molecular weight: 472.54

Ref: TM-T0191

Linagliptin

CAS: 668270-12-0

Linagliptin

Purity: 99%

Molecular weight: 472.54g/mol

Ref: 54-OR1028133

Linagliptin

CAS: 668270-12-0

Formula: C₂₅H₂₈N₈O₂

Color and Shape: Yellow Solid

Molecular weight: 472.55

Ref: 4Z-L-441

Linagliptin

CAS: 668270-12-0

Linagliptin

Purity: ≥98%

Molecular weight: 472.54g/mol

Ref: 54-BUP14681

Linagliptin

CAS: 668270-12-0

Formula: C₂₅H₂₈N₈O₂

Color and Shape: Neat

Molecular weight: 472.54

Ref: 86-MM3412.00

Linagliptin

CAS: 668270-12-0

Formula: C₂₅H₂₈N₈O₂

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 472.55

Ref: 3B-L0468

N-Nitroso Linagliptin Impurity 91

CAS: 668270-12-0

Formula: C₂₄H₂₅N₉O₃

Color and Shape: Yellow Solid

Molecular weight: 487.52

Ref: 4Z-L-44113

Linagliptin

CAS: 668270-12-0

Formula: C₂₅H₂₈N₈O₂

Purity: ≥ 98.0% (anhydrous basis)

Color and Shape: White, off-white or pale orange-yellow powder

Molecular weight: 472.54

Ref: 7W-GP5216

N-Nitroso Linagliptin Impurity 14

CAS: 668270-12-0

Formula: C₄₅H₄₃N₁₅O₅

Color and Shape: Yellow Solid

Molecular weight: 873.94

Ref: 4Z-L-44130

Linagliptin

CAS: 668270-12-0

Applications Linagliptin is a novel potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor with potential use in the treatment of type 2 diabetes.
References Prabavathy, N. et al.: Int. J. Pharm. Bio. Sci., 2, 438 (2011); Deacon, C.F.: Diab. Obes. Metab., 13, 7 (2011);

Formula: C₂₅H₂₈N₈O₂

Color and Shape: White To Orange

Molecular weight: 472.54

Ref: TR-L465900

Linagliptin Methyl Dimer

Controlled Product

CAS: 668270-12-0

Applications Linagliptin Methyldimer is an impurity of Linagliptin (L465900). Linagliptin is a novel potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor with potential use in the treatment of type 2 diabetes.
References Prabavathy, N. et al.: Int. J. Pharm. Bio. Sci., 2, 438 (2011); Deacon, C.F.: Diab. Obes. Metab., 13, 7 (2011)

Formula: C₅₁H₅₆N₁₆O₄

Color and Shape: Neat

Molecular weight: 957.095

Ref: TR-L465945

Linagliptin - Bio-X ™

CAS: 668270-12-0

Linagliptin is a dipeptidyl peptidase-4 inhibitor drug that is used to manage hyperglycaemia in patients with type 2 diabetes. This drug works by inhibiting the enzyme dipeptidyl peptidase-4 and allows for the breakdown of GLP-1 and glucose dependent insulinotropic polypeptide. As a result of this, breakdown of glycogen is reduced and release of insulin is increased. Linagliptin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₂₅H₂₈N₈O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 472.54 g/mol

Ref: 3D-BL164627

Linagliptin Impurity 106

CAS: 668270-12-0

Formula: C₅₇H₆₀N₁₆O₄

Color and Shape: Yellow Solid

Molecular weight: 1033.22

Ref: 4Z-L-44122

Linagliptin

CAS: 668270-12-0

Dipeptidyl peptidase-4 inhibitor

Formula: C₂₅H₂₈N₈O₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 472.54 g/mol

Ref: 3D-FL24893