CAS 668270-12-0

Linagliptin

Description:

Linagliptin is an oral antihyperglycemic agent primarily used in the management of type 2 diabetes mellitus. It belongs to the class of medications known as DPP-4 inhibitors, which work by increasing incretin levels, thereby enhancing insulin secretion and decreasing glucagon levels in a glucose-dependent manner. This mechanism helps to lower blood glucose levels without causing significant hypoglycemia. Linagliptin is characterized by its high selectivity for the DPP-4 enzyme, which contributes to its efficacy and safety profile. The substance is typically administered once daily due to its long half-life, allowing for convenient dosing. Linagliptin is also notable for its minimal renal excretion, making it suitable for patients with renal impairment. In terms of chemical properties, it has a molecular formula that reflects its complex structure, which includes multiple functional groups that contribute to its pharmacological activity. Overall, Linagliptin is recognized for its effectiveness in glycemic control and its favorable tolerability profile in diabetic patients.

Formula: C₂₅H₂₈N₈O₂

InChI: InChI=1S/C25H28N8O2/c1-4-5-13-32-21-22(29-24(32)31-12-8-9-17(26)14-31)30(3)25(35)33(23(21)34)15-20-27-16(2)18-10-6-7-11-19(18)28-20/h6-7,10-11,17H,8-9,12-15,26H2,1-3H3/t17-/m1/s1

InChI key: InChIKey=LTXREWYXXSTFRX-QGZVFWFLSA-N

SMILES: C(C#CC)N1C2=C(N=C1N3C[C@H](N)CCC3)N(C)C(=O)N(CC4=NC5=C(C(C)=N4)C=CC=C5)C2=O

Synonyms:

• (R)-8-[3-Aminopiperidin-1-yl]-7-(2-butynyl)-3-methyl-1-(4-methylquinazolin-2-ylmethyl)xanthine
• 1H-Purine-2,6-Dione, 8-[(3R)-3-Amino-1-Piperidinyl]-7-(2-Butyn-1-Yl)-3,7-Dihydro-3-Methyl-1-[(4-Methyl-2-Quinazolinyl)Methyl]-
• 1H-Purine-2,6-dione, 8-[(3R)-3-amino-1-piperidinyl]-7-(2-butynyl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-
• 8-[(3R)-3-Amino-1-piperidinyl]-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione
• 8-[(3R)-3-Amino-1-piperidinyl]-7-(2-butynyl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione
• 8-[(3R)-3-aminopiperidin-1-yl]-7-(but-2-yn-1-yl)-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-dione
• Bi 1356
• Bi 1356Bs
• Ondero
• Tradjenta
• Trajenta

Linagliptin

CAS: 668270-12-0

Formula: C₂₅H₂₈N₈O₂

Molecular weight: 472.5

Ref: BE-RMCL094000

Linagliptin

CAS: 668270-12-0

Formula: C₂₅H₂₈N₈O₂

Molecular weight: 472.5

Ref: BE-MU-7670

Linagliptin Methyl Dimer

Controlled Product

CAS: 668270-12-0

Applications Linagliptin Methyldimer is an impurity of Linagliptin (L465900). Linagliptin is a novel potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor with potential use in the treatment of type 2 diabetes.
References Prabavathy, N. et al.: Int. J. Pharm. Bio. Sci., 2, 438 (2011); Deacon, C.F.: Diab. Obes. Metab., 13, 7 (2011)

Formula: C₅₁H₅₆N₁₆O₄

Color and Shape: Neat

Molecular weight: 957.095

Ref: TR-L465945