CAS 66840-02-6

2'-deoxy-2'-fluorouridine 5'-(tetrahydrogen triphosphate)

Description:

2'-Deoxy-2'-fluorouridine 5'-(tetrahydrogen triphosphate), commonly referred to as dFUTP, is a modified nucleotide analog of uridine. It features a fluorine atom at the 2' position of the ribose sugar, which alters its biochemical properties compared to standard nucleotides. This modification can influence its incorporation into RNA and DNA during nucleic acid synthesis, potentially affecting the activity of various polymerases. The triphosphate form of dFUTP is crucial for its role in biochemical reactions, as it serves as a substrate for RNA and DNA synthesis. The presence of the fluorine atom can enhance the stability of the nucleotide and may confer resistance to certain nucleases. dFUTP is often used in molecular biology and biochemistry research, particularly in studies involving RNA synthesis and the development of antiviral therapies. Its CAS number, 66840-02-6, is a unique identifier that facilitates its recognition in chemical databases and literature. Overall, dFUTP is a valuable tool in the exploration of nucleic acid functions and interactions.

Formula: C₉H₁₄FN₂O₁₄P₃

InChI: InChI=1/C9H14FN2O14P3/c10-6-7(14)4(24-8(6)12-2-1-5(13)11-9(12)15)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,14H,3H2,(H,19,20)(H,21,22)(H,11,13,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1

SMILES: c1cn([C@H]2[C@@H]([C@@H]([C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)O)F)c(=O)nc1O

2'-Deoxy-2'-fluorouridine-5'-triphosphate tetralithium

CAS: 66840-02-6

2'-Deoxy-2'-fluorouridine-5'-triphosphate tetralithium (2'DFUR) is a fatty acid that is resistant to many antibacterial agents. 2'DFUR inhibits the biosynthesis of bacterial cell walls, leading to cell death. This drug has been shown to have potent antibacterial activity against Staphylococcus strains and other bacteria. The mechanism of action is not yet fully understood, but it may involve inhibition of nucleotidyltransferase and aminopropyl transferase enzymes.

Formula: C₉H₁₁FN₂O₁₄P₃Li₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 510.87 g/mol

Ref: 3D-ND09528

2'-Deoxy-2'-fluorouridine-5'-triphosphate sodium salt - 100mM aqueous solution

CAS: 66840-02-6

2'-Deoxy-2'-fluorouridine-5'-triphosphate sodium salt is an antibacterial agent with a potent antibacterial activity. It has been shown to be active against Gram-positive bacteria, including Staphylococcus aureus and Enterococcus faecalis. It also inhibits the synthesis of uronic acid and butyric acid, which are components of the bacterial cell wall. In addition, 2'-deoxy-2'-fluorouridine-5'-triphosphate sodium salt is able to inhibit nucleotidylyltransferase, which is an enzyme involved in the biosynthesis of fatty acids in bacteria.

Formula: C₉H₁₄FN₂O₁₄P₃·Na

Purity: Min. 95%

Molecular weight: 509.12 g/mol

Ref: 3D-ND157275