CAS 66849-34-1

(+)-Ifosfamide

Description:

(+)-Ifosfamide is a synthetic alkylating agent primarily used in chemotherapy for treating various cancers, including testicular cancer and sarcomas. It is a prodrug, meaning it requires metabolic activation to exert its therapeutic effects. The compound is characterized by its ability to form DNA cross-links, which inhibit DNA replication and transcription, ultimately leading to cell death. (+)-Ifosfamide is typically administered intravenously and is known for its moderate to severe side effects, including myelosuppression, neurotoxicity, and potential bladder toxicity, necessitating the use of protective agents like mesna to mitigate these risks. The compound has a chiral center, and its (+) enantiomer is the active form responsible for its anticancer activity. Its chemical structure includes a nitrogen mustard moiety, which is crucial for its mechanism of action. As with many chemotherapeutic agents, careful monitoring of patient response and side effects is essential during treatment. Overall, (+)-Ifosfamide plays a significant role in oncology, contributing to the management of specific malignancies.

Formula: C₇H₁₅Cl₂N₂O₂P

InChI: InChI=1/C7H15Cl2N2O2P/c8-2-4-10-14(12)11(6-3-9)5-1-7-13-14/h1-7H2,(H,10,12)/t14-/m1/s1

InChI key: InChIKey=HOMGKSMUEGBAAB-CQSZACIVSA-N

SMILES: C(CCl)N1P(NCCCl)(=O)OCCC1

Synonyms:

• (R)-Ifosfamide
• (+)-Ifosfamide
• (+)-Ifosphamide
• 2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis(2-chloroethyl)tetrahydro-, 2-oxide, (2R)-
• 2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis(2-chloroethyl)tetrahydro-, 2-oxide, (R)-
• L Ifosfamide,LIfosfamide
• (2-CHLORO-ETHYL)-[(R)-3-(2-CHLORO-ETHYL)-2-OXO-2LAMBDA5-[1,3,2]OXAZAPHOSPHINAN-2-YL]-AMINE
• L-Ifosfamide

L-Ifosfamide

CAS: 66849-34-1

L-Ifosfamide, a nitrogen mustard alkylating agent, differs from cyclophosphamide in antitumor activity and spectrum.

Formula: C₇H₁₅Cl₂N₂O₂P

Color and Shape: Solid

Molecular weight: 261.09

Ref: TM-T25723