CAS 66898-62-2

Talniflumate

Description:

Talniflumate is a chemical compound classified as a non-steroidal anti-inflammatory drug (NSAID) primarily used for its analgesic and anti-inflammatory properties. It is characterized by its ability to inhibit the synthesis of prostaglandins, which are mediators of inflammation and pain. Talniflumate is often utilized in the treatment of various inflammatory conditions, including arthritis and other musculoskeletal disorders. The compound exhibits a moderate to high solubility in organic solvents, which can influence its bioavailability and pharmacokinetics. Its mechanism of action involves the modulation of cyclooxygenase enzymes, leading to reduced inflammation and pain relief. Additionally, talniflumate may have a favorable safety profile compared to traditional NSAIDs, with a lower incidence of gastrointestinal side effects. However, like all medications, it should be used under medical supervision, considering potential interactions and contraindications. Overall, talniflumate represents a valuable option in the management of pain and inflammation in clinical settings.

Formula: C₂₁H₁₃F₃N₂O₄

InChI: InChI=1S/C21H13F3N2O4/c22-21(23,24)12-5-3-6-13(11-12)26-17-16(9-4-10-25-17)19(28)30-20-15-8-2-1-7-14(15)18(27)29-20/h1-11,20H,(H,25,26)

InChI key: InChIKey=ANMLJLFWUCQGKZ-UHFFFAOYSA-N

SMILES: O(C(=O)C1=C(NC2=CC(C(F)(F)F)=CC=C2)N=CC=C1)C3C=4C(C(=O)O3)=CC=CC4

Synonyms:

• (3-Oxo-1H-2-benzofuran-1-yl) 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylate
• 2-(3-Trifluoromethyl-phenylamino)-nicotinic acid 3-oxo-1,3-dihydro-isobenzofuran-1-yl ester
• 2-[[3-(Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic Acid 1,3-Dihydro-3-oxo-1-isobenzofuranyl Ester
• 3-Oxo-1,3-Dihydro-2-Benzofuran-1-Yl 2-{[3-(Trifluoromethyl)Phenyl]Amino}Pyridine-3-Carboxylate
• 3-Oxo-1,3-dihydro-2-benzofuran-1-yl 2-{[3-(trifluoromethyl)phenyl]amino}nicotinate
• 3-Pyridinecarboxylic acid, 2-[[3-(trifluoromethyl)phenyl]amino]-, 1,3-dihydro-3-oxo-1-isobenzofuranyl ester
• 66898-62-2
• Ba 7602-06
• Sml 1710
• Somalgen
• Talniflumate
• Talniflumate (BA 7602-06)
• 3-pyridinecarboxylic acid 2-{[(3-trifluoromethyl)phenyl]amino}-1,3-dihydro-3-oxo-1-soenzofuranyl ester
• TALNIFLUMATE(INTERMEDIATE)
• 3-ftalidilicodelacido2-((3-(trifluormetil)fenil)amino)-3-piridincarboxilic
• 2-[[3-(Trifluoromethyl)phenyl]amino]-1,3-dihydro-3-oxo-1-isobenzofuranyl3-pyridinecarboxylicacidester
• phthalidyl2-(3-trifluoromethylanilino)nicotinate
• 2-(alpha,alpha,alpha-trifluoro-m-toluidino)-nicotinicaciphthalidylester
• 2-[3-(trifluoromethyl)anilino]-3-pyridinecarboxylic acid (3-oxo-1H-isobenzofuran-1-yl) ester
• 2-(α,α,α-Trifluoro-m-toluidino)nicotinic acid phthalidyl ester
• phthalidyl2-(alpha,alpha,alpha-trifluoro-m-toluidino)nicotinate
• 2-(alpha,alpha,alpha-trifluoro-m-toluidino)nicotinicacidphthalidylester
• 3-phthalidylesterof2-((3-(trifluoromethyl)phenyl)amino)-3-pyridinecarboxyl
• 2-[[3-(Trifluoromethyl)phenyl]amino]nicotinic acid 1,3-dihydro-3-oxoisobenzofuran-1-yl ester
• Talniflumate, >=99%

Talniflumate

CAS: 66898-62-2

Formula: C₂₁H₁₃F₃N₂O₄

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Yellow powder to crystal

Molecular weight: 414.34

Ref: 3B-T3101

[(1R)-3-oxo-1H-2-benzofuran-1-yl] 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylate

CAS: 66898-62-2

Formula: C₂₁H₁₃F₃N₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 414.3341

Ref: IN-DA00IMKI

Talniflumate

CAS: 66898-62-2

Talniflumate

Purity: 98%

Molecular weight: 414.34g/mol

Ref: 54-PC108958

Talniflumate

CAS: 66898-62-2

Talniflumate

Purity: ≥98%

Molecular weight: 414.33g/mol

Ref: 54-BUP05375

Talniflumate

CAS: 66898-62-2

Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell

Formula: C₂₁H₁₃F₃N₂O₄

Purity: 98% - 99.81%

Color and Shape: White To Pale Yellow Crystalline Powder

Molecular weight: 414.33

Ref: TM-T4503

Talniflumate

Controlled Product

CAS: 66898-62-2

Stability Acid Sensitive, Moisture Sensitive
Applications Talniflumate is a nonaspirin and nonsteroidal anti-inflammatory drug.
References Choi, N., et al.: Stroke, 39, 845 (2008)

Formula: C₂₁H₁₃F₃N₂O₄

Color and Shape: Off White To Light Green

Molecular weight: 414.33

Ref: TR-T005575

Talniflumate

CAS: 66898-62-2

Talniflumate is a fatty acid that is chemically similar to the natural product linoleic acid. It has been shown to be effective at preventing and treating infections caused by infectious diseases, such as malaria and tuberculosis. Talniflumate has also been used in the treatment of autoimmune diseases like psoriasis and systemic lupus erythematosus. Talniflumate has low bioavailability, which may be due to its high lipophilicity or a lack of solubility in water. The analytical method for talniflumate is based on an LC-MS/MS technique that uses nanocapillary columns with high resolution mass spectrometry detection. This method can measure concentrations as low as 10 ng/mL of talniflumate in biological samples.

Formula: C₂₁H₁₃F₃N₂O₄

Purity: Min. 95%

Color and Shape: White Clear Liquid

Molecular weight: 414.33 g/mol

Ref: 3D-FT60430

TALNIFLUMATE

CAS: 66898-62-2

Purity: 98%

Molecular weight: 414.3399963

Ref: 10-F801738