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CAS 66917-44-0

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Betamethasone 9,11-epoxide 17,21-dipropionate

Description:
Betamethasone 9,11-epoxide 17,21-dipropionate is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties. It is derived from betamethasone, a potent glucocorticoid, and features an epoxide group at the 9 and 11 positions, which enhances its biological activity. The dipropionate esterification at the 17 and 21 positions increases its lipophilicity, allowing for improved skin penetration and prolonged action when used in topical formulations. This compound is typically utilized in the treatment of various inflammatory skin conditions, allergies, and autoimmune disorders. Its mechanism of action involves the modulation of gene expression, leading to reduced production of pro-inflammatory cytokines and mediators. Betamethasone 9,11-epoxide 17,21-dipropionate is characterized by its high potency, low systemic bioavailability when applied topically, and a favorable safety profile when used as directed. However, like all corticosteroids, it may have side effects, particularly with prolonged use, including skin thinning and potential systemic effects if absorbed in significant amounts.
Formula:C28H36O7
InChI:InChI=1S/C28H36O7/c1-6-23(31)33-15-21(30)27(35-24(32)7-2)16(3)12-20-19-9-8-17-13-18(29)10-11-25(17,4)28(19)22(34-28)14-26(20,27)5/h10-11,13,16,19-20,22H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,22-,25-,26-,27-,28+/m0/s1
InChI key:InChIKey=BWSCDDHHJUGBSQ-XHYJHYNESA-N
SMILES:C[C@@]12[C@@]34[C@@](O3)(C[C@@]5(C)[C@]([C@@]4(CCC1=CC(=O)C=C2)[H])(C[C@H](C)[C@@]5(C(COC(CC)=O)=O)OC(CC)=O)[H])[H]
Synonyms:
  • (9β,11β,16β)-9,11-Epoxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione
  • Pregna-1,4-diene-3,20-dione, 9,11-epoxy-16-methyl-17,21-bis(1-oxopropoxy)-, (9β,11β,16β)-
  • Betamethasone 9,11-epoxide 17,21-dipropionate
  • Betamethasone 9β,11β-epoxide 17,21-dipropionate
  • Beclometasone Propionate EP Impurity J
  • 2-oxo-2-((4aS,4bS,5aS,6aS,7R,8S,9aS,9bS)-4a,6a,8-trimethyl-2-oxo-7-(propionyloxy)-2,4a,5a,6,6a,7,8,9,9a,9b,10,11-dodecahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-7-yl)ethyl propionate
  • Beclomethasone Propionate Impurity J(EP)
  • Beclometasone Dipropionate EP Impurity J (Betamethasone Dipropionate EP Impurity F)
  • Betamethasone Dipropionate impurity 4/Betamethasone Dipropionate EP Impurity F/Beclomethasone Dipropionate EP Impurity J/9,11?-Epoxy-16?-methyl-3,20-dioxo-9?-pregna-1,4-diene-17,21-diyl dipropanoate
  • Betamethasone Dipropionate Impurity 6（Betamethasone Dipropionate EP Impurity F）
  • See more synonyms
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