CAS 66969-81-1

Tiodazosin

Description:

Tiodazosin is a pharmaceutical compound primarily classified as an alpha-1 adrenergic antagonist, which is used in the treatment of conditions such as hypertension and benign prostatic hyperplasia. Its mechanism of action involves blocking alpha-1 adrenergic receptors, leading to vasodilation and a subsequent decrease in blood pressure. Tiodazosin is characterized by its chemical structure, which includes a thiazole ring and a piperazine moiety, contributing to its pharmacological properties. The compound is typically administered orally and exhibits a moderate half-life, allowing for once-daily dosing in clinical settings. Its solubility profile indicates that it is more soluble in organic solvents than in water, which can influence its bioavailability. As with many medications, potential side effects may include dizziness, headache, and orthostatic hypotension. Overall, Tiodazosin represents a valuable option in the management of certain cardiovascular and urological conditions, with ongoing research exploring its efficacy and safety profile in various patient populations.

Formula: C₁₈H₂₁N₇O₄S

InChI: InChI=1S/C18H21N7O4S/c1-27-12-8-10-11(9-13(12)28-2)20-17(21-14(10)19)25-6-4-24(5-7-25)16(26)15-22-23-18(29-15)30-3/h8-9H,4-7H2,1-3H3,(H2,19,20,21)

InChI key: InChIKey=MULPYFRDYRZMDS-UHFFFAOYSA-N

SMILES: NC=1C2=C(N=C(N1)N3CCN(C(=O)C=4OC(SC)=NN4)CC3)C=C(OC)C(OC)=C2

Synonyms:

• 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((5-(methylthio)-1,3,4-oxadiazol-2-yl)carbonyl)-piperazine
• 2-(4-((5-Methylthio-1,3,4-oxadiazol-2-yl)carbonyl)piperazino)-6,7-dimethoxy-4-chinazolinamin
• Bl 5111
• Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl][5-(methylthio)-1,3,4-oxadiazol-2-yl]-
• Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((5-(methylthio)-1,3,4-oxadiazol-2-yl)carbonyl)-
• Tiodazosin [USAN:INN]
• Tiodazosina
• Tiodazosina [INN-Spanish]
• Tiodazosine
• Tiodazosine [INN-French]
• Tiodazosinum
• Tiodazosinum [INN-Latin]
• Unii-Fqi0Pyj799
• [4-(4-Amino-6,7-Dimethoxyquinazolin-2-Yl)Piperazin-1-Yl][5-(Methylsulfanyl)-1,3,4-Oxadiazol-2-Yl]Methanone
• [4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl][5-(methylthio)-1,3,4-oxadiazol-2-yl]methanone

Tiodazosin

CAS: 66969-81-1

Tiodazosin is a pharmaceutical dosage form of Tiodazosin that is a polymeric matrix. It is used to treat hypertension and benign prostatic hyperplasia. Tiodazosin has been shown to increase renal blood flow by inhibiting the activity of α1-acid glycoprotein, which in turn increases the synthesis and release of nitric oxide from vascular endothelial cells. This drug also has been shown to have antihypertensive effects by blocking receptor activity at adrenoreceptors, thereby decreasing the production of catecholamines at sympathetic nerve endings. Tiodazosin is metabolized in the liver by fatty acid oxidation, with subsequent degradation by fatty alcohols and α1-acid glycoprotein. The process can be monitored using a chromatographic method on human plasma.

Formula: C₁₈H₂₁N₇O₄S

Purity: Min. 95%

Molecular weight: 431.5 g/mol

Ref: 3D-RCA96981

Tiodazosin

CAS: 66969-81-1

Tiodazosin is a competitive antagonist of the postsynaptic alpha-adrenergic receptor.

Formula: C₁₈H₂₁N₇O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 431.47

Ref: TM-T13162