CAS 67018-85-3

Norverapamil

Description:

Norverapamil is a chemical compound that belongs to the class of calcium channel blockers, primarily used in the treatment of cardiovascular conditions. It is a derivative of verapamil, which is known for its ability to inhibit calcium ion influx across cell membranes, thereby relaxing vascular smooth muscle and reducing heart rate. Norverapamil exhibits similar pharmacological properties, making it effective in managing hypertension and certain types of arrhythmias. The compound is characterized by its lipophilicity, which influences its absorption and distribution in the body. It typically presents as a white to off-white crystalline powder and is soluble in organic solvents but has limited solubility in water. The molecular structure of norverapamil includes a piperidine ring and a phenyl group, contributing to its biological activity. As with many pharmaceuticals, its use may be accompanied by side effects, and it is essential to monitor patients for potential drug interactions. Overall, norverapamil serves as an important therapeutic agent in cardiovascular medicine.

Formula: C₂₆H₃₆N₂O₄

InChI: InChI=1S/C26H36N2O4/c1-19(2)26(18-27,21-9-11-23(30-4)25(17-21)32-6)13-7-14-28-15-12-20-8-10-22(29-3)24(16-20)31-5/h8-11,16-17,19,28H,7,12-15H2,1-6H3

InChI key: InChIKey=UPKQNCPKPOLASS-UHFFFAOYSA-N

SMILES: C(CCCNCCC1=CC(OC)=C(OC)C=C1)(C(C)C)(C#N)C2=CC(OC)=C(OC)C=C2

Synonyms:

• 2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethylamino]-2-propan-2-ylpentanenitrile
• 2-(3,4-Dimethoxyphenyl)-5-{[2-(3,4-Dimethoxyphenyl)Ethyl]Amino}-2-(Propan-2-Yl)Pentanenitrile
• 2-(3,4-Dimethoxyphenyl)-5-{[2-(3,4-Dimethoxyphenyl)Ethyl]Amino}-2-(Propan-2-Yl)Pentanenitrile Hydrochloride (1:1)
• 5-((3,4-Dimethoxyphenethyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile
• Benzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)amino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-
• Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-
• D 591
• Norverapamil
• Valeronitrile, 5-[(3,4-dimethoxyphenethyl)amino]-2-(3,4-dimethoxyphenyl)-2-isopropyl-
• alpha-(3-((2-(3,4-Dimethoxyphenyl)ethyl)amino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile
• α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile

Verapamil EP Impurity J

CAS: 67018-85-3

Formula: C₂₆H₃₆N₂O₄

Molecular weight: 440.58

Ref: ST-EA-CP-V10010

Norverapamil

CAS: 67018-85-3

Norverapamil is a blocker of L-type calcium channel and an inhibitor of P-glycoprotein (P-gp) function .

Formula: C₂₆H₃₆N₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 440.58

Ref: TM-T12244