CAS 67022-39-3

Methotrexate EP Impurity H (Methotrexate-5-Monomethyl Ester)

CAS: 67022-39-3

Formula: C₂₁H₂₄N₈O₅

Color and Shape: Yellow Solid

Molecular weight: 468.47

Ref: 4Z-M-708

Methotrexate γ-Methyl Ester

CAS: 67022-39-3

Methotrexate γ-Methyl Ester

Purity: 98%

Ref: 54-OR1039768

Methotrexate 5-methyl ester

CAS: 67022-39-3

Methotrexate 5-methyl ester is an impurity of Methotrexate which is a folic acid antagonist. It's used as an antineoplastic and antirheumatic.

Formula: C₂₁H₂₄N₈O₅

Color and Shape: Solid

Molecular weight: 468.47

Ref: TM-T25797

(2S)-2-[[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]amino]-5-methoxy-5-oxopentanoic Acid (Methotrexate 5-Methyl Ester)

CAS: 67022-39-3

Color and Shape: Neat

Ref: 86-MM0040.23

Methotrexate γ-Methyl Ester

Controlled Product

CAS: 67022-39-3

Impurity Methotrexate EP Impurity H
Applications Methotrexate γ-methyl ester is an impurity of Methotrexate (M260675), a folic acid antagonist. Used as a antineoplastic and antirheumatic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),

Formula: C₂₁H₂₄N₈O₅

Color and Shape: Neat

Molecular weight: 468.47

Ref: TR-M260705

Methotrexate-5-monomethyl ester

CAS: 67022-39-3

Methotrexate-5-monomethyl ester is an analytical standard that is synthesized synthetically. The synthetic route used to produce the compound has been optimized for high purity, making this product suitable for use as a drug product or impurity standard. The structure of methotrexate-5-monomethyl ester was confirmed by 1H and 13C NMR spectroscopy and mass spectrometry. Methotrexate-5-monomethyl ester is an impurity found in the synthesis of methotrexate and is a metabolite of methotrexate. It has been shown to inhibit DNA synthesis and protein synthesis in animal cells, which may be due to its ability to inhibit transcription factors such as NFATc1, NFkB, STAT3, STAT5A and STAT5B.

Formula: C₂₁H₂₄N₈O₅

Purity: Min. 95%

Molecular weight: 468.47 g/mol

Ref: 3D-IM71453

Methotrexate EP Impurity H

CAS: 67022-39-3

Formula: C₂₁H₂₄N₈O₅

Molecular weight: 468.5

Ref: ST-EA-CP-M12008