CAS 670220-88-9

Crenolanib

Description:

Crenolanib is a small molecule inhibitor primarily known for its selective targeting of the receptor tyrosine kinases, particularly the platelet-derived growth factor receptor (PDGFR) and the fibroblast growth factor receptor (FGFR). It is classified as a kinase inhibitor and is notable for its potential therapeutic applications in treating various cancers, especially those with mutations in the PDGFR gene. Crenolanib exhibits a unique mechanism of action by binding to the active site of the kinase, thereby inhibiting its phosphorylation activity, which is crucial for tumor cell proliferation and survival. The compound is typically administered orally and has been investigated in clinical trials for its efficacy and safety profile in patients with specific hematological malignancies and solid tumors. Its chemical structure includes a complex arrangement of functional groups that contribute to its biological activity and pharmacokinetic properties. As with many targeted therapies, the development and use of crenolanib are accompanied by ongoing research to optimize its application and understand resistance mechanisms in cancer treatment.

Formula: C₂₆H₂₉N₅O₂

InChI: InChI=1S/C26H29N5O2/c1-26(14-32-15-26)16-33-20-6-7-22-21(13-20)28-17-31(22)24-8-5-18-3-2-4-23(25(18)29-24)30-11-9-19(27)10-12-30/h2-8,13,17,19H,9-12,14-16,27H2,1H3

InChI key: InChIKey=DYNHJHQFHQTFTP-UHFFFAOYSA-N

SMILES: NC1CCN(C=2C3=C(C=CC(=N3)N4C=5C(N=C4)=CC(OCC6(C)COC6)=CC5)C=CC2)CC1

Synonyms:

• 1-[2-[5-[(3-Methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine
• 1-[2-[5-[(3-Methyloxetan-3-yl)methoxy]benzimidazol-1-yl]quinolin-8-yl]piperidin-4-amine
• 4-Piperidinamine, 1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-
• Aro 002
• Cp 868596
• [1-[2-[5-(3-Methyloxetan-3-ylmethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-yl]amine
• Crenolanib
• Crenolanib (CP-868596)
• CP868569/Crenolanib
• Crenolanib (CP-868569)
• [1-[2-[5-(3-Methyloxetan-3-ylmethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-yl]amine Crenolanib ,ARO 002
• 1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine
• Crenolanib, >=98%
• 1-(2-(5-((3-Methyloxetan-3-yl)methoxy)-1H-benzo-[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-ami
• cp-868596 crenolanib

Crenolanib (CP-868596)

CAS: 670220-88-9

Formula: C₂₆H₂₉N₅O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 443.5408

Ref: IN-DA00FBZQ

1-[2-[5-[(3-Methyl-3-Oxetanyl)Methoxy]-1-Benzimidazolyl]-8-Quinolyl]-4-Piperidinamine

CAS: 670220-88-9

1-[2-[5-[(3-Methyl-3-Oxetanyl)Methoxy]-1-Benzimidazolyl]-8-Quinolyl]-4-Piperidinamine

Purity: 98%

Molecular weight: 443.54g/mol

Ref: 54-OR1023313

Crenolanib

CAS: 670220-88-9

Crenolanib

Purity: ≥95%

Molecular weight: 443.54g/mol

Ref: 54-BUP10081

Crenolanib

CAS: 670220-88-9

Formula: C₂₆H₂₉N₅O₂

Molecular weight: 443.55

Ref: 4Z-C-258001

Crenolanib

CAS: 670220-88-9

Crenolanib (ARO 002) is an orally bioavailable type III tyrosine kinases inhibitor of PDGFRα/β and FLT3 (IC50s: 11, 3.2, and 4 nM).

Formula: C₂₆H₂₉N₅O₂

Purity: 98.40% - 99.73%

Color and Shape: Solid

Molecular weight: 443.54

Ref: TM-T2677

Crenolanib

CAS: 670220-88-9

Inhibits type III tyrosine kinases (PDGFRα, PDGFRβ, FLT3)

Formula: C₂₆H₂₉N₅O₂

Purity: Min. 95%

Color and Shape: White To Yellow Solid

Molecular weight: 443.54 g/mol

Ref: 3D-FC29756

Crenolanib

Controlled Product

CAS: 670220-88-9

Formula: C₂₆H₂₉N₅O₂

Color and Shape: Neat

Molecular weight: 443.541

Ref: TR-C781795