CAS 670220-88-9: Crenolanib

Description: Crenolanib is a small molecule inhibitor primarily known for its selective targeting of the receptor tyrosine kinases, particularly the platelet-derived growth factor receptor (PDGFR) and the fibroblast growth factor receptor (FGFR). It is classified as a kinase inhibitor and is notable for its potential therapeutic applications in treating various cancers, especially those with mutations in the PDGFR gene. Crenolanib exhibits a unique mechanism of action by binding to the active site of the kinase, thereby inhibiting its phosphorylation activity, which is crucial for tumor cell proliferation and survival. The compound is typically administered orally and has been investigated in clinical trials for its efficacy and safety profile in patients with specific hematological malignancies and solid tumors. Its chemical structure includes a complex arrangement of functional groups that contribute to its biological activity and pharmacokinetic properties. As with many targeted therapies, the development and use of crenolanib are accompanied by ongoing research to optimize its application and understand resistance mechanisms in cancer treatment.

Formula: C₂₆H₂₉N₅O₂

InChI: InChI=1S/C26H29N5O2/c1-26(14-32-15-26)16-33-20-6-7-22-21(13-20)28-17-31(22)24-8-5-18-3-2-4-23(25(18)29-24)30-11-9-19(27)10-12-30/h2-8,13,17,19H,9-12,14-16,27H2,1H3

InChI key: InChIKey=DYNHJHQFHQTFTP-UHFFFAOYSA-N

SMILES: N1=CN(C=2N=C3C(C=CC=C3N4CCC(N)CC4)=CC2)C=5C=CC(OCC6(C)COC6)=CC15

Synonyms:

• 1-[2-[5-[(3-Methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine
• 1-[2-[5-[(3-Methyloxetan-3-yl)methoxy]benzimidazol-1-yl]quinolin-8-yl]piperidin-4-amine
• 4-Piperidinamine, 1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-
• Aro 002
• Cp 868596
• [1-[2-[5-(3-Methyloxetan-3-ylmethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-yl]amine
• Crenolanib

Crenolanib (CP-868596)

CAS: 670220-88-9

• Formula: C₂₆H₂₉N₅O₂
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 443.5408

1-[2-[5-[(3-Methyl-3-Oxetanyl)Methoxy]-1-Benzimidazolyl]-8-Quinolyl]-4-Piperidinamine

CAS: 670220-88-9

• Purity: 98%
• Molecular weight: 443.54g/mol

Crenolanib

CAS: 670220-88-9

• Purity: ≥95%
• Molecular weight: 443.54g/mol

Crenolanib

CAS: 670220-88-9

• Formula: C₂₆H₂₉N₅O₂
• Molecular weight: 443.55

Crenolanib

CAS: 670220-88-9

Crenolanib (ARO 002) is an orally bioavailable type III tyrosine kinases inhibitor of PDGFRα/β and …

• Formula: C₂₆H₂₉N₅O₂
• Purity: 97.45% - 99.28%
• Color and Shape: Solid
• Molecular weight: 443.54

Crenolanib

CAS: 670220-88-9

Inhibits type III tyrosine kinases (PDGFRα, PDGFRβ, FLT3)

• Formula: C₂₆H₂₉N₅O₂
• Purity: Min. 95%
• Color and Shape: White To Yellow Solid
• Molecular weight: 443.54 g/mol

Crenolanib

CAS: 670220-88-9

• Formula: C₂₆H₂₉N₅O₂
• Color and Shape: Neat
• Molecular weight: 443.541