CAS 67025-98-3

(5alpha,6beta)-6-[bis(2-chloroethyl)amino]-17-(cyclopropylmethyl)-4,5-epoxymorphinan-3,14-diol dihydrochloride

Description:

The chemical substance known as (5alpha,6beta)-6-[bis(2-chloroethyl)amino]-17-(cyclopropylmethyl)-4,5-epoxymorphinan-3,14-diol dihydrochloride, with the CAS number 67025-98-3, is a synthetic opioid derivative. It features a morphinan backbone, which is characteristic of many opioids, and includes a unique epoxide group that contributes to its pharmacological properties. The presence of the bis(2-chloroethyl)amino group suggests potential for enhanced interaction with biological targets, possibly increasing its potency or altering its pharmacokinetics. The cyclopropylmethyl substituent may influence the compound's receptor affinity and selectivity. As a dihydrochloride salt, it is likely to be more soluble in aqueous environments, which is beneficial for formulation in pharmaceutical applications. This compound may exhibit analgesic effects, but its specific therapeutic uses, side effects, and safety profile would require further investigation through clinical studies. Overall, its structural features indicate potential utility in pain management or as a research tool in opioid receptor studies.

Formula: C₂₄H₃₄Cl₄N₂O₃

InChI: InChI=1/C24H32Cl2N2O3.2ClH/c25-8-11-27(12-9-26)17-5-6-24(30)19-13-16-3-4-18(29)21-20(16)23(24,22(17)31-21)7-10-28(19)14-15-1-2-15;;/h3-4,15,17,19,22,29-30H,1-2,5-14H2;2*1H/t17-,19-,22+,23+,24-;;/m1../s1

Synonyms:

• (5Α,6Β)-6-[Bis(2-Chloroethyl)Amino]-17-(Cyclopropylmethyl)-4,5-Epoxymorphinan-3,14-Diol Dihydrochloride

β-Chlornaltrexamine dihydrochloride

CAS: 67025-98-3

β-Chlornaltrexamine dihydrochloride (β-CNA dihydrochloride) is an effective long-term antagonist of opioid receptors. It efficiently blocks the inhibition of dopamine release mediated by κ opioid receptor agonists. This compound is useful in the research of pain perception mechanisms.

Formula: C₂₄H₃₄Cl₄N₂O₃

Molecular weight: 540.35

Ref: TM-T88669

β-Chlornaltrexamine dihydrochloride

CAS: 67025-98-3

Formula: C₂₄H₃₂Cl₂N₂O₃·2HCl

Molecular weight: 540.35

Ref: 7W-GL1825

β-Chlornaltrexamine dihydrochloride

Controlled Product

CAS: 67025-98-3

β-Chlornaltrexamine dihydrochloride (β-CNTA) is a non-competitive antagonist of the kappa opioid receptor. It has been shown to inhibit camp levels and whole-cell recordings in cells expressing the G protein, guanine nucleotide binding proteins, and ryanodine receptor. β-CNTA also inhibits locomotor activity in mice and reverses the effects of morphine on rotarod performance. In addition, β-CNTA has been shown to be effective against human cell line HL60.END>

Formula: C₂₄H₃₂Cl₂N₂O₃•2HCl

Purity: Min. 95%

Molecular weight: 540.35 g/mol

Ref: 3D-SCA02598