CAS 672-87-7

Metyrosine

Description:

Metyrosine, also known as alpha-methyltyrosine, is an aromatic amino acid derivative with the chemical formula C9H11NO3. It is primarily recognized for its role as a competitive inhibitor of the enzyme tyrosine hydroxylase, which is crucial in the biosynthesis of catecholamines such as dopamine, norepinephrine, and epinephrine. Metyrosine is utilized in clinical settings, particularly for the management of pheochromocytoma, a tumor of the adrenal gland that secretes excess catecholamines. The substance is characterized by its white to off-white crystalline powder form and is soluble in water and alcohol. Its mechanism of action involves reducing catecholamine production, thereby alleviating symptoms associated with catecholamine excess. Metyrosine is typically administered orally and may have side effects, including sedation and gastrointestinal disturbances. As a pharmaceutical agent, it is important to monitor its use under medical supervision to manage potential interactions and contraindications effectively.

Formula: C₁₀H₁₃NO₃

InChI: InChI=1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)/t10-/m0/s1

InChI key: InChIKey=NHTGHBARYWONDQ-JTQLQIEISA-N

SMILES: C([C@](C(O)=O)(C)N)C1=CC=C(O)C=C1

Synonyms:

• (2S)-2-Amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid
• (S)-2-(4-Hydroxybenzyl)-2-aminopropanoic acid
• (S)-α-Methyltyrosine
• <span class="text-smallcaps">L</span>(-)-Metyrosine
• <span class="text-smallcaps">L</span>-Tyrosine, α-methyl-
• <span class="text-smallcaps">L</span>-α-MT
• <span class="text-smallcaps">L</span>-α-Methyl-p-tyrosine
• <span class="text-smallcaps">L</span>-α-Methyltyrosine
• Demser
• L(-)-Metyrosine
• L-α-MT
• L-α-Methyl-p-tyrosine
• L-α-Methyltyrosine
• Metirosin
• Metirosina
• Metirosine
• Metyrosine
• Mk 781
• Tyrosine, α-methyl-, <span class="text-smallcaps">L</span>-
• Tyrosine, α-methyl-, L-
• α-Methyl-<span class="text-smallcaps">L</span>-tyrosine
• α-Methyl-L-tyrosine
• L-Tyrosine, α-methyl-

Metyrosine

CAS: 672-87-7

Aromatic amino-alcohol-phenols, aromatic amino-acid-phenols and other aromatic amino compounds with oxygen function

Formula: C₁₀H₁₃NO₃

Color and Shape: White Crystalline Powder

Molecular weight: 195.22

Ref: 45-1443205

α-Methyl-L-tyrosine

CAS: 672-87-7

Formula: C₁₀H₁₃NO₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 195.2151

Ref: IN-DA003NSF

Metyrosine

CAS: 672-87-7

Metyrosine

Purity: 95%

Molecular weight: 195.22g/mol

Ref: 54-OR1027560

Metyrosine

CAS: 672-87-7

Metyrosine

Purity: ≥98%

Molecular weight: 195.22g/mol

Ref: 54-BUP14013

α-Methyl-L-p-tyrosine

CAS: 672-87-7

Formula: C₁₀H₁₃NO₃

Purity: (NMR) ≥ 97%

Color and Shape: White to off-white powder or solid

Molecular weight: 195.2

Ref: 7W-GC3195

Metyrosine

CAS: 672-87-7

Metyrosine: antihypertensive, tyrosine hydroxylase inhibitor, controls COX-2, lowers blood pressure.

Formula: C₁₀H₁₃NO₃

Purity: 98.68% - 99.72%

Color and Shape: Solid

Molecular weight: 195.22

Ref: TM-T22368

(S)-2-Amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid

CAS: 672-87-7

Formula: C₁₀H₁₃NO₃

Purity: 95%

Color and Shape: Liquid, No data available.

Molecular weight: 195.218

Ref: 10-F324725

Alpha-Methyl-L-tyrosine

Controlled Product

CAS: 672-87-7

Applications A tyrosine hydroxylase inhibitor. An antihypertensive in pheochromocytoma.
References Espin, J., et al.: Biochem. J., 331, 547 (1998), Espin, J., et al.: J. Agric. Food Chem., 47, 3495 (1999), Espin, J., et al.: Eur. J. Biochem., 267, 1270 (2000), Battaini, G., et al.: J. Biol. Chem., 277, 44606 (2002),

Formula: C₁₀H₁₃NO₃

Color and Shape: Neat

Molecular weight: 195.22

Ref: TR-M332700

a-Me-Tyr-OH

CAS: 672-87-7

a-Me-Tyr-OH is a neurotoxin that binds to the 2-adrenergic receptor and inhibits neurotransmission. It has been shown to have a number of effects on monoamine neurotransmitters, including dopamine and serotonin. The binding of this compound to the 2-adrenergic receptor in the caudate putamen has been shown to be associated with behavioral changes in rats, including locomotor activity and exploratory behavior. This agent also affects neurochemical processes in the hippocampus, causing neuronal death. The effect of this compound on blood sampling is not known.

Formula: C₁₀H₁₃NO₃

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 195.22 g/mol

Ref: 3D-FM72860