CAS 67227-56-9

Fenoldopam

Description:

Fenoldopam is a selective dopamine D1 receptor agonist primarily used in clinical settings for the management of hypertension, particularly in acute situations. It is characterized by its ability to induce vasodilation, leading to a decrease in blood pressure without significantly affecting heart rate. The chemical structure of fenoldopam includes a 2-amino-5-(1,2-benzodioxol-5-yl)-2-methylpropan-1-ol backbone, which contributes to its pharmacological properties. Fenoldopam is administered intravenously and has a rapid onset of action, making it suitable for acute care scenarios. Its mechanism of action involves the activation of dopamine receptors, which promotes renal blood flow and diuresis, thus providing additional benefits in patients with renal impairment. The substance is generally well-tolerated, with side effects that may include headache, flushing, and gastrointestinal disturbances. Due to its specific receptor targeting, fenoldopam is distinguished from other antihypertensive agents, offering a unique approach to blood pressure management.

Formula: C₁₆H₁₆ClNO₃

InChI: InChI=1S/C16H16ClNO3/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21/h1-4,7,13,18-21H,5-6,8H2

InChI key: InChIKey=TVURRHSHRRELCG-UHFFFAOYSA-N

SMILES: ClC1=C2C(C(CNCC2)C3=CC=C(O)C=C3)=CC(O)=C1O

Synonyms:

• (±)-Skf 82526
• 1H-3-benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-
• 266-612-7
• 6-Chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol
• 6-Chloro-7,8-dihydroxy-1-p-hydroxyphenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
• 6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
• 6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol hydrochloride
• Skf 82526-J
• Fenoldopam

Fenoldopam

CAS: 67227-56-9

Fenoldopam is a selective D1-like dopamine receptor partial agonist (EC50 = 57 nM).

Formula: C₁₆H₁₆ClNO₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 305.76

Ref: TM-T22779