CAS 6724-53-4

Perhexiline maleate

Description:

Perhexiline maleate is a pharmaceutical compound primarily used as an antianginal agent, particularly in the treatment of ischemic heart disease. It functions as a metabolic modulator, enhancing myocardial energy metabolism by shifting the substrate utilization from fatty acids to glucose, which is more efficient under ischemic conditions. The substance is a salt formed from perhexiline, a tertiary amine, and maleic acid. Perhexiline maleate is typically administered orally and is known for its relatively long half-life, necessitating careful monitoring of plasma levels to avoid toxicity. Its pharmacokinetics can be influenced by genetic variations in liver enzymes, particularly CYP2D6, leading to differences in metabolism among individuals. Common side effects may include gastrointestinal disturbances and neurological symptoms, such as dizziness or tremors. Due to its potential for serious adverse effects, including hepatotoxicity, its use is often limited to specific patient populations under close medical supervision. Overall, perhexiline maleate represents a unique approach to managing angina through metabolic modulation rather than traditional vasodilatory mechanisms.

Formula: C₁₉H₃₅N·C₄H₄O₄

InChI: InChI=1S/C19H35N.C4H4O4/c1-3-9-16(10-4-1)19(17-11-5-2-6-12-17)15-18-13-7-8-14-20-18;5-3(6)1-2-4(7)8/h16-20H,1-15H2;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key: InChIKey=JDZOTSLZMQDFLG-BTJKTKAUSA-N

SMILES: C(CC1CCCCN1)(C2CCCCC2)C3CCCCC3.C(=C\C(O)=O)\C(O)=O

Synonyms:

• (Z)-but-2-enedioate
• 2-(2,2-Dicyclohexylethyl)Piperidin-1-Ium
• 2-(2,2-Dicyclohexylethyl)piperidine acid maleate
• 2-(2,2-Dicyclohexylethyl)piperidine maleate
• 2-(2,2-Dicyclohexylethyl)piperidine maleate (1:1)
• 2-(2,2-Dicyclohexylethyl)piperidinium hydrogen maleate
• Ccris 5491
• Perhexilene maleate
• Perhexiline maleate [USAN]
• Pexid
• Piperidine, 2-(2,2-dicyclohexylethyl)-, (2Z)-2-butenedioate (1:1)
• Piperidine, 2-(2,2-dicyclohexylethyl)-, (Z)-2-butenedioate (1:1)
• Piperidine, 2-(2,2-dicyclohexylethyl)-, maleate
• Piperidine, 2-(2,2-dicyclohexylethyl)-, maleate (1:1)
• Unii-K7V8Y90G0H

Perhexiline maleate

CAS: 6724-53-4

Perhexiline maleate is an orally active inhibitor of CPT1 and CPT2 that reduces fatty acid metabolism.

Formula: C₂₃H₃₉NO₄

Purity: 99.77% - ≥98%

Color and Shape: Solid

Molecular weight: 393.56

Ref: TM-T12408

Perhexiline maleate salt

CAS: 6724-53-4

Formula: C₂₃H₃₉NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 393.5601

Ref: IN-DA003TNJ

Perhexiline maleate salt

CAS: 6724-53-4

Formula: C₁₉H₃₅N·C₄H₄O₄

Molecular weight: 393.56

Ref: 7W-GL3083

2-(2,2-Dicyclohexylethyl)Piperidine Maleate

CAS: 6724-53-4

2-(2,2-Dicyclohexylethyl)Piperidine Maleate

Purity: 98%

Molecular weight: 393.56g/mol

Ref: 54-OR1023145

Perhexiline maleate

CAS: 6724-53-4

Perhexiline maleate

Purity: ≥98%

Molecular weight: 393.56g/mol

Ref: 54-BUP09880

Perhexiline Maleate

CAS: 6724-53-4

Formula: C₁₉H₃₅N·C₄H₄O₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 393.57

Ref: 3B-P3145

Perhexiline-d11 Maleate (Mixture of Diastereomers)

Controlled Product

CAS: 6724-53-4

Formula: C₁₉D₁₁H₂₄N·C₄H₄O₄

Color and Shape: Neat

Molecular weight: 404.63

Ref: TR-P287322

rac Perhexiline Maleate

Controlled Product

CAS: 6724-53-4

Applications Vasodilator, used in treatments for angina.
References Miyamoto, S., et al.: Toxicol. Mech. Method., 19, 477 (2009), Perez-Reyes, E., et al.: J. Pharmacol. Exper. Ther., 328, 621(2009), Isoherranen, N., et al.: Chem. Res. Toxicol., 22, 294 (2009),

Formula: C₁₉H₃₅N·C₄H₄O₄

Color and Shape: Neat

Molecular weight: 393.56

Ref: TR-P287320

rac-Perhexiline maleate

CAS: 6724-53-4

Inhibitor of CPT1 and CPT2 enzymes; inhibitor of mTORC1 kinase; anti-fungal

Formula: C₂₃H₃₉NO₄

Purity: Min. 97 Area-%

Color and Shape: White To Off-White Solid

Molecular weight: 393.56 g/mol

Ref: 3D-FP27567