CAS 67308-21-8

cefaclor iMpurity G

Description:

Cefaclor Impurity G, with the CAS number 67308-21-8, is a chemical compound associated with the antibiotic cefaclor, which is a second-generation cephalosporin. This impurity is typically a byproduct of the synthesis of cefaclor and may arise during the manufacturing process. Cefaclor itself is known for its broad-spectrum antibacterial activity, particularly against Gram-positive and some Gram-negative bacteria. Impurities like Cefaclor Impurity G can affect the purity and efficacy of the final pharmaceutical product. Characteristically, impurities may exhibit different solubility, stability, and reactivity compared to the parent compound. The presence of such impurities is critical to monitor in pharmaceutical formulations to ensure safety, efficacy, and compliance with regulatory standards. Analytical techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry are commonly employed to identify and quantify impurities in drug substances. Understanding the characteristics of impurities is essential for quality control in pharmaceutical manufacturing.

Formula: C₁₆H₁₇N₃O₄S

Synonyms:

• cefaclor iMpurity G
• 5-Thia-1-azabicyclo[4.2.0]octane-2-carboxylic acid, 7-[(aminophenylacetyl)amino]-3-methylene-8-oxo-, [6R-[6α,7β(R*)]]- (9CI)
• Cefaclor impurity 8/Cefaclor EP Impurity G/(2S,6R,7R)-7-((R)-2-amino-2-phenylacetamido)-3-methylene-8-oxo-5-thia-1-azabicyclo[4.2.0]octane-2-carboxylic acid
• Cefaclor Impurity 7(Cefaclor EP Impurity G)
• AcetazolaMide IMpurity B
• (2R,6R,7R)- AND (2S,6R,7R)-7-[[(2R)-2-AMINO-2-PHENYLACETYL]AMINO]-3-METHYLENE-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCTANE-2-CARBOXYLIC ACID (ISOCEFALEXINE)
• 6R-[6α,7β(R*)]]-7-[(Aminophenylacetyl)amino]-3-methylene-8-oxo-5-thia-1-azabicyclo[4.2.0]octane-2-carboxylic Acid

Cefaclor EP Impurity G

CAS: 67308-21-8

Formula: C₁₆H₁₇N₃O₄S

Molecular weight: 347.40

Ref: 4Z-C-666

[6R-[6α,7β(R*)]]-7-[(Aminophenylacetyl)amino]-3-methylene-8-oxo-5-thia-1-azabicyclo[4.2.0]octane-2-carboxylic Acid

Controlled Product

CAS: 67308-21-8

Stability Light Sensitive
Applications [6R-[6α,7β(R*)]]-7-[(Aminophenylacetyl)amino]-3-methylene-8-oxo-5-thia-1-azabicyclo[4.2.0]octane-2-carboxylic Acid is an impurity of Cefaclor (C235250), an second-generation cephalosporin antibiotic for antibacterial purposes.
References Gray, B.M., et al.: Antimicrob. Agents Chemother., 13, 988 (1978), Lorenz, L.J., et al.: Anal. Profiles Drug Subs., 9, 107 (1980), Hori, R., et al.: J. Pharm. Pharmacol., 40, 646 (1988),

Formula: C₁₆H₁₇N₃O₄S

Color and Shape: Neat

Molecular weight: 347.39

Ref: TR-A622260

Cefaclor EP Impurity G

CAS: 67308-21-8

Formula: C₁₆H₁₇N₃O₄S

Molecular weight: 347.39

Ref: ST-EA-CP-C60007