CAS 6736-03-4

Echothiophate

Description:

Echothiophate is a synthetic organophosphate compound primarily used as a medication in the treatment of glaucoma and as a miotic agent to constrict the pupil of the eye. It functions as an irreversible inhibitor of the enzyme acetylcholinesterase, leading to increased levels of acetylcholine at synapses, which enhances cholinergic activity. This characteristic makes it effective in reducing intraocular pressure. Echothiophate is a colorless to pale yellow liquid with a slightly oily consistency and is soluble in water and organic solvents. Its chemical structure includes a thiophosphate group, which contributes to its biological activity and toxicity profile. Due to its mechanism of action, echothiophate can have side effects related to excessive cholinergic stimulation, such as muscle twitching, salivation, and respiratory distress. Safety precautions are necessary when handling this compound, as it can be toxic in higher doses. Overall, echothiophate exemplifies the dual nature of organophosphates, serving therapeutic purposes while also posing potential risks.

Formula: C₉H₂₃NO₃PS

InChI: InChI=1S/C9H23NO3PS/c1-6-12-14(11,13-7-2)15-9-8-10(3,4)5/h6-9H2,1-5H3/q+1

InChI key: InChIKey=BJOLKYGKSZKIGU-UHFFFAOYSA-N

SMILES: P(SCC[N+](C)(C)C)(OCC)(OCC)=O

Synonyms:

• (2-Mercaptoethyl)trimethylammonium S-ester with O,O'-diethylphosphorothioate
• 2-[(Diethoxyphosphinyl)thio]-N,N,N-trimethylethanaminium
• 6736-03-4
• Ammonium, (2-mercaptoethyl)trimethyl-, S-ester with O,O-diethyl phosphorothioate
• Echothiophate
• Ecothiopate
• Ecothiopatum
• Ecothiophate
• Ethanaminium, 2-[(diethoxyphosphinyl)thio]-N,N,N-trimethyl-
• Phospholine
• Phospholine (pharmaceutical)

Echothiophate-d3 Iodide

Controlled Product

CAS: 513-10-0, 6736-03-4

Applications Echothiophate-d3 Iodide is labelled Echothiophate Iodide (E325800), an anticholinesterase drug.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ashani, Y., et al.: Biochem. Pharm., 30, 2593 (1981)

Formula: C₉D₃H₂₀NO₃PS·I

Color and Shape: Neat

Molecular weight: 386.245

Ref: TR-E325802