CAS 67401-56-3

Micrococcin P1

Description:

Micrococcin P1 is a peptide antibiotic produced by certain strains of the bacterium Micrococcus luteus. It is characterized by its ability to inhibit bacterial protein synthesis, making it effective against a range of Gram-positive bacteria. The structure of Micrococcin P1 consists of a cyclic peptide, which contributes to its stability and resistance to enzymatic degradation. This antibiotic exhibits a unique mechanism of action by binding to the ribosomal subunit, thereby interfering with the translation process. Micrococcin P1 is notable for its low toxicity to mammalian cells, which enhances its potential therapeutic applications. Additionally, it has been studied for its potential use in food preservation and as a model for developing new antibiotics. Its CAS number, 67401-56-3, is a unique identifier that facilitates the tracking and study of this compound in scientific literature and regulatory databases. Overall, Micrococcin P1 represents an important area of research in the field of antimicrobial agents and antibiotic resistance.

Formula: C₄₈H₄₉N₁₃O₉S₆

InChI: InChI=1S/C48H49N13O9S6/c1-8-24(37(65)49-12-20(5)62)51-38(66)28-15-73-46(56-28)32-18-74-45(58-32)26-11-10-23-36(50-26)27-13-75-48(53-27)35(22(7)64)61-41(69)31-17-76-47(57-31)33(19(3)4)59-39(67)30-16-72-44(55-30)25(9-2)52-42(70)34(21(6)63)60-40(68)29-14-71-43(23)54-29/h8-11,13-22,33-35,62-64H,12H2,1-7H3,(H,49,65)(H,51,66)(H,52,70)(H,59,67)(H,60,68)(H,61,69)/b24-8-,25-9-/t20-,21-,22-,33+,34+,35+/m1/s1

InChI key: InChIKey=MQGFYNRGFWXAKA-QMXXNAFJSA-N

SMILES: [C@H](C)(O)[C@]1(C2=NC(C=3C(C4=NC(=CS4)C(=O)N[C@@]([C@@H](C)O)(C(=O)N/C(=C\C)/C5=NC(C(=O)N[C@@H](C(C)C)C6=NC(C(=O)N1)=CS6)=CS5)[H])=CC=C(N3)C7=NC(=CS7)C8=NC(C(N/C(/C(NC[C@@H](C)O)=O)=C\C)=O)=CS8)=CS2)[H]

Synonyms:

• Micrococcin P1
• [2,4′-Bithiazole]-4-carboxamide, 2′-[(11S,14Z,21S,28S)-14-ethylidene-9,10,11,12,13,14,20,21,27,28-decahydro-28-[(1R)-1-hydroxyethyl]-11-[(1R)-1-hydroxyethyl]-21-(1-methylethyl)-9,12,19,26-tetraoxo-19H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-N-[(1Z)-1-[[[(2R)-2-hydroxypropyl]amino]carbonyl]-1-propen-1-yl]-
• [2,4′-Bithiazole]-4-carboxamide, 2′-[(11S,14Z,21S,28S)-14-ethylidene-9,10,11,12,13,14,20,21,27,28-decahydro-28-[(1R)-1-hydroxyethyl]-11-[(1R)-1-hydroxyethyl]-21-(1-methylethyl)-9,12,19,26-tetraoxo-19H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-N-[(1Z)-1-[[[(2R)-2-hydroxypropyl]amino]carbonyl]-1-propenyl]-
• 2′-[(11S,14Z,21S,28S)-14-Ethylidene-9,10,11,12,13,14,20,21,27,28-decahydro-28-[(1R)-1-hydroxyethyl]-11-[(1R)-1-hydroxyethyl]-21-(1-methylethyl)-9,12,19,26-tetraoxo-19H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-N-[(1Z)-1-[[[(2R)-2-hydroxypropyl]amino]carbonyl]-1-propen-1-yl][2,4′-bithiazole]-4-carboxamide

Micrococcin P1

CAS: 67401-56-3

Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor(EC50 range of 0.1-0.5 μM)

Formula: C₄₈H₄₉N₁₃O₉S₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 1144.36

Ref: TM-T12033

Micrococcin P1

CAS: 67401-56-3

Micrococcin P1 is a natural compound that has been shown to inhibit the growth of human pathogens. It is an inhibitor of microbial RNA polymerase, and it binds to the enzyme's active site. Micrococcin P1 inhibits bacterial growth by binding to the 50S ribosomal subunit in a similar manner as rifampicin and is used for the treatment of infectious diseases. This drug also exhibits pharmacokinetic properties that are different from other antimicrobial agents, such as trifluoroacetic acid. Micrococcin P1 has been shown to be bound in serum at concentrations higher than those found in plasma or urine, suggesting that it may be metabolized by serum proteins.

Formula: C₄₈H₄₉N₁₃O₉S₆

Purity: Min. 95%

Molecular weight: 1,144.4 g/mol

Ref: 3D-SCA40156