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CAS 6741-73-7

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4′-Thiouridine

Description:
4′-Thiouridine is a modified nucleoside that features a sulfur atom in place of the oxygen atom at the 4′ position of the ribose sugar moiety of uridine. This structural modification imparts unique properties to the molecule, influencing its biological activity and stability. It is primarily known for its role in RNA metabolism and is often found in tRNA, where it contributes to the stability and function of the molecule. 4′-Thiouridine exhibits a range of biochemical properties, including the ability to participate in hydrogen bonding and base pairing, which can affect the folding and interaction of RNA structures. Additionally, it has been studied for its potential therapeutic applications, particularly in antiviral and anticancer research, due to its ability to modulate cellular processes. The compound is soluble in water and exhibits a relatively low toxicity profile, making it a subject of interest in various biochemical studies. Overall, 4′-Thiouridine serves as an important tool in molecular biology and biochemistry, providing insights into nucleic acid function and regulation.
Formula:C9H12N2O5S
InChI:InChI=1S/C9H12N2O5S/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1
InChI key:InChIKey=MUSPKJVFRAYWAR-XVFCMESISA-N
SMILES:O[C@H]1[C@@H](S[C@H](CO)[C@H]1O)N2C(=O)NC(=O)C=C2
Synonyms:
  • Uridine, 4′-thio-
  • 4′-Thiouridine
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