CAS 67410-65-5

2-Amino-8-β-D-ribofuranosylimidazo[1,2-a]-1,3,5-triazin-4(8H)-one

Description:

2-Amino-8-β-D-ribofuranosylimidazo[1,2-a]-1,3,5-triazin-4(8H)-one, with the CAS number 67410-65-5, is a nucleoside analog that exhibits structural features characteristic of both purines and pyrimidines. This compound contains an imidazo[1,2-a]triazine core, which is fused to a ribofuranosyl moiety, contributing to its biological activity. The presence of an amino group at the 2-position and a hydroxyl group on the ribofuranosyl ring enhances its solubility and potential interactions with biological macromolecules. This compound is of interest in medicinal chemistry and biochemistry due to its potential role in nucleic acid metabolism and as a substrate for various enzymes. Its unique structure may also confer specific binding properties to nucleic acid targets, making it a candidate for further research in antiviral or anticancer therapies. Overall, the compound's characteristics suggest a complex interplay between its structural features and biological functions, warranting further investigation into its pharmacological applications.

Formula: C₁₀H₁₃N₅O₅

InChI: InChI=1S/C10H13N5O5/c11-8-12-9-14(1-2-15(9)10(19)13-8)7-6(18)5(17)4(3-16)20-7/h1-2,4-7,16-18H,3H2,(H2,11,13,19)/t4-,5-,6-,7-/m1/s1

InChI key: InChIKey=ZQUTYCUKRGSIGL-DBRKOABJSA-N

SMILES: O=C1N2C(N(C=C2)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)=NC(N)=N1

Synonyms:

• 5-Aza-7-deazaguanosine
• ZX 2401
• Imidazo[1,2-a]-1,3,5-triazin-4(8H)-one, 2-amino-8-β-D-ribofuranosyl-
• 2-Amino-8-β-D-ribofuranosylimidazo[1,2-a]-1,3,5-triazin-4(8H)-one
• NSC 344511

5-Aza-7-deazaguanosine

CAS: 67410-65-5

Formula: C₁₀H₁₃N₅O₅

Purity: ≥ 95.0%

Color and Shape: Conflicting attributes defined

Molecular weight: 283.24

Ref: 7W-GN7686

5-Aza-7-deazaguanosine

CAS: 67410-65-5

5-Aza-7-deazaguanosine is a nucleoside analogue that has antiviral activity against herpes simplex virus, influenza, and other DNA viruses. 5-Aza-7-deazaguanosine is an analog of guanosine with the addition of a 7-deaza group on the nitrogen atom. This drug inhibits viral replication by inhibiting the polymerase function of the viral NS5B protein, which is essential for DNA synthesis. The structure activity relationship studies have shown that this compound has anti-hepatitis B virus activity, but not against hepatitis C virus. 5-Aza-7-deazaguanosine has been shown to be effective in animal models as well as in humans without any significant toxicity issues.

Formula: C₁₀H₁₃N₅O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 283.24 g/mol

Ref: 3D-NA09785

5-Aza-7-deaza Guanosine

Controlled Product

CAS: 67410-65-5

Applications Nucleosides as antiviral agent for the treatment of influenza; broad-spectrum inhibitor of viruses in the Flaviviridae family.
References Sidwell, R.W., et al.: Appl. Microbiol., 22, 797 (1971), Allen, B., et al.: J. Med. Che,., 18, 721 (1976),

Formula: C₁₀H₁₃N₅O₅

Color and Shape: Neat

Molecular weight: 283.24

Ref: TR-A628915