CAS 6745-93-3

L-Glutamic acid,N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, monohydrate(9CI)

Description:

L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, monohydrate, commonly referred to by its CAS number 6745-93-3, is a complex organic compound that features a pteridine moiety, which is a bicyclic structure containing nitrogen atoms. This substance is characterized by its amino acid backbone, specifically L-glutamic acid, which is known for its role as a neurotransmitter and its involvement in various metabolic processes. The compound exhibits hydrophilic properties due to the presence of multiple amino and carboxyl groups, contributing to its solubility in water. It is typically found in a monohydrate form, indicating the presence of one water molecule per molecule of the compound, which can influence its stability and solubility. The pteridinyl group suggests potential biological activity, possibly related to its role in cellular processes or as a precursor in the synthesis of other biologically relevant molecules. Overall, this compound may have applications in biochemistry and pharmacology, particularly in studies related to neurotransmission and metabolic pathways.

Formula: C₂₀H₂₂N₈O₅

Synonyms:

• Glutamicacid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-,monohydrate, L- (8CI)
• Methotrexate monohydrate
• D-AMETHOPTERIN HYDRATE, 95
• L-Glutamic acid, N-4-(2,4-diamino-6-pteridinyl)methylmethylaminobenzoyl-, monohydrate

Methotrexate monohydrate

CAS: 6745-93-3

Methotrexate monohydrate inhibits DHFR, enhances T cell apoptosis, reduces activation, and suppresses cytokines.

Formula: C₂₀H₂₄N₈O₆

Color and Shape: Solid

Molecular weight: 472.45

Ref: TM-T28027

N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methyl- amino]benzoyl]-L-glutamic acid

CAS: 6745-93-3

N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid is a kinase inhibitor that has been shown to induce apoptosis in cancer cells. It is an analog of neopterin, a protein found in urine that is associated with cancer. This compound inhibits kinases involved in the regulation of cell growth and division, making it an effective anticancer agent. The inhibition of these kinases leads to the suppression of tumor growth and the induction of apoptosis, which results in the death of cancer cells. N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid has been tested on human cancer cell lines as well as Chinese hamster ovary cells and has shown potent anticancer activity. This compound may be useful for developing new inhibitors for other types of tumors.

Formula: C₂₀H₂₄N₈O₆

Purity: Min. 95%

Molecular weight: 472.5 g/mol

Ref: 3D-GAA74593