CAS 675126-05-3

Dasotraline

Description:

Dasotraline is a novel chemical compound primarily recognized for its potential use in treating psychiatric disorders, particularly attention-deficit hyperactivity disorder (ADHD). It functions as a dual inhibitor of the dopamine and norepinephrine transporters, which enhances the availability of these neurotransmitters in the synaptic cleft, thereby improving mood and attention. Dasotraline is characterized by its relatively long half-life, allowing for once-daily dosing, which can improve patient compliance. The compound exhibits a favorable pharmacokinetic profile, with good oral bioavailability and a manageable side effect profile compared to traditional stimulant medications. Its chemical structure includes specific functional groups that contribute to its activity and selectivity for the target transporters. Ongoing research continues to evaluate its efficacy and safety in various populations, making it a compound of interest in the field of psychopharmacology. As with any medication, the therapeutic use of dasotraline should be guided by clinical evidence and tailored to individual patient needs.

Formula: C₁₆H₁₅Cl₂N

InChI: InChI=1S/C16H15Cl2N/c17-14-7-5-10(9-15(14)18)11-6-8-16(19)13-4-2-1-3-12(11)13/h1-5,7,9,11,16H,6,8,19H2/t11-,16+/m0/s1

InChI key: InChIKey=SRPXSILJHWNFMK-MEDUHNTESA-N

SMILES: N[C@H]1C=2C([C@@H](CC1)C3=CC(Cl)=C(Cl)C=C3)=CC=CC2

Synonyms:

• SEP 225289
• 1-Naphthalenamine, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-, (1R,4S)-
• Dasotraline
• (1R,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine

Dasotraline

CAS: 675126-05-3

Formula: C₁₆H₁₅Cl₂N

Purity: 98%

Molecular weight: 292.2030

Ref: IN-DA00FFPQ

Dasotraline

CAS: 675126-05-3

Dasotraline: a triple reuptake inhibitor targeting DA, NE, and 5-HT with IC50 values of 4, 6, 11 nM. Possible new antidepressant class.

Formula: C₁₆H₁₅Cl₂N

Color and Shape: Solid

Molecular weight: 292.2

Ref: TM-T60607

Dasotraline

CAS: 675126-05-3

Dasotraline is a dopamine and norepinephrine reuptake inhibitor (DNRI), which is a small-molecule pharmaceutical developed for potential therapeutic use. This compound originates from synthetic chemical processes designed to modulate neurotransmitter activity within the central nervous system. The mode of action of dasotraline involves the inhibition of dopamine and norepinephrine transporters. By blocking the reuptake of these neurotransmitters, dasotraline increases their extracellular concentrations, thereby enhancing dopaminergic and noradrenergic signaling.

Formula: C₁₆H₁₅Cl₂N

Purity: Min. 95%

Molecular weight: 292.2 g/mol

Ref: 3D-ACB12605