CAS 675576-97-3

Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-meth ylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-

Description:

Piperazinone, with the specified structure and CAS number 675576-97-3, is a synthetic organic compound characterized by its complex molecular architecture, which includes a piperazine ring and an imidazole moiety. This compound features multiple aromatic substituents, including chlorophenyl groups and a methoxy-phenyl group, contributing to its potential biological activity. The presence of the carbonyl group indicates that it may participate in various chemical reactions, such as nucleophilic attacks or hydrogen bonding. Piperazinones are often studied for their pharmacological properties, including potential applications in medicinal chemistry, particularly in the development of therapeutic agents. The stereochemistry of the compound, denoted by the (4R,5S) configuration, suggests specific spatial arrangements that can influence its interaction with biological targets. Overall, the unique combination of functional groups and stereochemistry in this compound may lead to interesting properties and activities, warranting further investigation in drug discovery and development.

Formula: C₃₀H₃₀Cl₂N₄O₄

Nutlin-3b

CAS: 675576-97-3

Nutlin-3b

Purity: ≥98%

Molecular weight: 581.49g/mol

Ref: 54-BUP02996

Nutlin-3b

CAS: 675576-97-3

Nutlin-3b, a less potent (+)-enantiomer of Nutlin-3, inhibits p53/MDM2 at IC50: 13.6 μM, 150x weaker than Nutlin-3a.

Formula: C₃₀H₃₀Cl₂N₄O₄

Purity: 98.83%

Color and Shape: Solid

Molecular weight: 581.49

Ref: TM-T6614

Nutlin-3b

CAS: 675576-97-3

Nutlin-3b is a small molecule that inhibits the activity of the tumor suppressor protein Mcl-1. Nutlin-3b binds to Mcl-1 and prevents its interaction with other proteins, resulting in decreased levels of Mcl-1 and increased apoptosis. It has been shown to be active in vitro against a variety of human cancer cell lines, including HL60 cells. In addition, Nutlin-3b has minimal toxicity in animal models and significant cytotoxicity against malignant cells. This compound is also effective against Mcl-deficient cell lines, suggesting that it may have potential as an anticancer drug for patients with acquired resistance to other chemotherapeutic agents.

Formula: C₃₀H₃₀Cl₂N₄O₄

Purity: Min. 95%

Molecular weight: 581.49 g/mol

Ref: 3D-ACB57697