CAS 675576-98-4: (-)-Nutlin 3

Description: (-)-Nutlin 3 is a small molecule inhibitor that primarily targets the interaction between the p53 tumor suppressor protein and its negative regulator, MDM2. This compound is part of a class of compounds known as MDM2 antagonists, which are of significant interest in cancer research due to their potential to reactivate p53, thereby promoting apoptosis in cancer cells. Chemically, (-)-Nutlin 3 is characterized by its specific stereochemistry, which is crucial for its biological activity. It typically exhibits a high affinity for the MDM2 protein, leading to the stabilization of p53 and the subsequent activation of p53-dependent pathways involved in cell cycle arrest and apoptosis. The compound is often studied for its therapeutic potential in various cancers, particularly those with wild-type p53. In terms of solubility, (-)-Nutlin 3 is generally soluble in organic solvents, and its pharmacokinetic properties are being explored to optimize its efficacy and bioavailability in clinical settings.

Formula: C₃₀H₃₀Cl₂N₄O₄

InChI: InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1

InChI key: InChIKey=BDUHCSBCVGXTJM-WUFINQPMSA-N

SMILES: O=C1NCCN(C(=O)N2C(=NC(C3=CC=C(Cl)C=C3)C2C4=CC=C(Cl)C=C4)C=5C=CC(OC)=CC5OC(C)C)C1

Synonyms:

• (-)-Nutlin 3
• 2-Piperazinone, 4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-
• 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl]carbonyl]piperazin-2-one
• Nutlin-3a
• Piperazinone, 4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-
• Sml 0580
• 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone

4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone

CAS: 675576-98-4

• Formula: C₃₀H₃₀Cl₂N₄O₄
• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 581.4896

4-[[(4S, 5R)-4,5-Bis(4-Chlorophenyl)-4,5-Dihydro-2-[4-Methoxy-2-(1-Methylethoxy)Phenyl]-1H-Imidazol-1-Yl]Carbonyl]-2-Piperazinone

CAS: 675576-98-4

• Molecular weight: 581.49g/mol

Nutlin-3a

CAS: 675576-98-4

• Purity: 99.05%
• Molecular weight: 581.49g/mol

Nutlin-3a

CAS: 675576-98-4

Nutlin-3a is the active enantiomer of Nutlin-3, an MDM2 antagonist that inhibits MDM2-p53 interaction. Nutlin-3a …

• Formula: C₃₀H₃₀Cl₂N₄O₄
• Purity: 95.62% - 99.71%
• Color and Shape: Solid
• Molecular weight: 581.49

MDM2 Antagonist IV, Nutlin-3a

CAS: 675576-98-4

Nutlin-3a is a potent and selective inhibitor of the MDM2 protein, which is an important …

• Formula: C₃₀H₃₀Cl₂N₄O₄
• Purity: Min. 95%
• Molecular weight: 581.49 g/mol