CAS 67655-94-1

Amastatin

Description:

Amastatin is a potent and selective inhibitor of aminopeptidases, particularly effective against the enzyme aminopeptidase N (APN). It is a naturally occurring compound derived from the fermentation of certain microorganisms, specifically from the actinomycete species. Amastatin is characterized by its ability to inhibit the hydrolysis of amino acids from the N-terminus of peptides, which plays a crucial role in various biological processes, including protein metabolism and immune response modulation. The compound has garnered interest in pharmaceutical research due to its potential applications in treating diseases where aminopeptidase activity is implicated, such as cancer and viral infections. Amastatin is typically studied in biochemical assays to evaluate its efficacy and specificity, and its structure includes a unique arrangement of amino acids that contributes to its inhibitory activity. As with many bioactive compounds, understanding its mechanism of action and potential side effects is essential for its development in therapeutic contexts.

Formula: C₂₁H₃₈N₄O₈

InChI: InChI=1/C21H38N4O8/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33)/t12-,13+,15+,16+,17+/m1/s1

Synonyms:

• Brn 4727847
• N-((2S,3R)-3-Amino-2-hydroxy-5-methyl-1-oxohexyl)-L-valyl-L-valyl-L-aspartic acid
• L-Aspartic acid, N-((2S,3R)-3-amino-2-hydroxy-5-methyl-1-oxohexyl)-L-valyl-L-valyl-
• L-Aspartic acid, N-(N-(3-amino-2-hydroxy-5-methyl-1-oxohexyl)-L-valyl)-L-valyl)-, (S-(R*,S*))-
• L-Aspartic acid, N-(N-(N-(3-amino-2-hydroxy-5-methyl-1-oxohexyl)-L-valyl)-L-valyl)-, (S-(R*,S*))-
• N-[(2S,3R)-3-amino-2-hydroxyheptanoyl]-L-norvalyl-L-norvalyl-L-aspartic acid
• N-[(2S,3R)-3-amino-2-hydroxy-5-methylhexanoyl]-L-valyl-L-valyl-L-aspartic acid

Amastatin

CAS: 67655-94-1

Amastatin

Formula: C₂₁H₃₈N₄O₈

Purity: By hplc: >99% (Typical Value in Batch COA)

Color and Shape: white powder

Molecular weight: 474.55g/mol

Ref: 54-BIMI3764

Amastatin

CAS: 67655-94-1

Amastatin is a synthetic product that inhibits peptidases. It is an inhibitor of the protease enzyme and can be used in the treatment of bladder infections caused by Chlamydia parvum. Amastatin has also been shown to inhibit Aminopeptidase, which is an enzyme that cleaves amino acids from proteins, thereby inhibiting protein synthesis. Amastatin has been shown to have an inhibitory effect on proteases in the striatal membranes of rats and may be useful in treating neurodegenerative disorders such as Parkinson's disease.

Formula: C₂₁H₃₈N₄O₈

Purity: Min. 95%

Molecular weight: 474.55 g/mol

Ref: 3D-IAM-4095

Amastatin

CAS: 67655-94-1

Amastatin is a natural protease inhibitor that has been shown to bind to the active site of serine proteases, such as trypsin and chymotrypsin. It also binds to other peptide substrates, such as angiotensin II, vasopressin and bradykinin. Amastatin is used in research as a tool for the study of protein interactions, receptor-ligand binding and ion channel activity. Amastatin is an activator of the high-affinity state of the beta-adrenergic receptor.

Formula: C₂₁H₃₈N₄O₈

Purity: Min. 95%

Molecular weight: 474.55 g/mol

Ref: 3D-IAM-4095-V

Amastatin

CAS: 67655-94-1

Amastatin is a natural compound that possesses antimicrobial activity. Amastatin has been shown to bind to the enzyme aminopeptidase, which is involved in the synthesis of peptide hormones and peptides. Amastatin also inhibits the activity of polymerase chain, an enzyme that catalyzes the production of RNA from DNA. The binding of amastatin to these enzymes causes cell lysis, leading to cell death.

Formula: C₂₁H₃₈N₄O₈

Purity: Min. 95%

Molecular weight: 474.5 g/mol

Ref: 3D-SCA65594

Amastatin

CAS: 67655-94-1

Amastatin is a non-toxic inhibitor of aminopeptidase A and leucine aminopeptidase, and its Ki for aminopeptidase A is 1 μM .

Formula: C₂₁H₃₈N₄O₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 474.55

Ref: TM-T22255