CAS 677-43-0

Dimethylphosphoramidic dichloride

Description:

Dimethylphosphoramidic dichloride, with the CAS number 677-43-0, is an organophosphorus compound characterized by its phosphoramidic structure. It typically appears as a colorless to pale yellow liquid and is known for its reactivity, particularly due to the presence of chlorine atoms, which can participate in nucleophilic substitution reactions. This compound is soluble in organic solvents but has limited solubility in water. It is primarily used in the synthesis of various phosphorus-containing compounds and as an intermediate in the production of agrochemicals and pharmaceuticals. Dimethylphosphoramidic dichloride is also recognized for its potential toxicity and should be handled with care, as it can cause irritation to the skin, eyes, and respiratory system. Proper safety measures, including the use of personal protective equipment, are essential when working with this substance. Its chemical properties make it a valuable reagent in organic synthesis, particularly in the development of compounds with biological activity.

Formula: C₂H₆Cl₂NOP

InChI: InChI=1S/C2H6Cl2NOP/c1-5(2)7(3,4)6/h1-2H3

InChI key: InChIKey=YNHXBEVSSILHPI-UHFFFAOYSA-N

SMILES: P(N(C)C)(Cl)(Cl)=O

Synonyms:

• (Dimethylamido)phosphoric dichloride
• (Dimethylamino)phosphoric dichloride
• Dichloro(dimethylamino)phosphine oxide
• Dichlorophosphoric dimethylamide
• Dimethylamidophosphoric acid dichloride
• Dimethylaminophosphoryl dichloride~N,N-Dimethylphosphoramic dichloride~DMPADC
• Dimethylphosphoramidic Dichloride
• Dimethylphosphorodichloridic amide
• N,N-Dimethylaminophosphoryl dichloride
• N,N-Dimethylphosphoramidic dichloride
• NSC 203138
• Phosphoramidic dichloride, N,N-dimethyl-

N,N-Dimethylphosphoramidodichloridate, 97%

CAS: 677-43-0

N,N-Dimethylphosphoramidodichloridate is used in the synthesis of phosphoramidates as well as (RS)-ethyl N,N-dimethylphosphoramidocyanidate (Nerve agent GA) which is used as a chemical weapon. It forms active intermediates, which react with alcohols in situ to give esters. It is also used to convert

Formula: C₂H₆Cl₂NOP

Purity: 97%

Molecular weight: 161.95

Ref: 02-L07231

N,N-Dimethylphosphoramidodichloridate

Controlled Product

CAS: 677-43-0

Stability Moisture Sensitive
Applications N,N-Dimethylphosphoramidodichloridate functions as a reagent used in the inhibition of acetylcholinestrase and butyryl cholinestrase by nerve agent surrogates. Also, the are used as reagents in the synthesis and in the antitumor activity of nonsymmetric phosphoric acid triamides.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Meek, E. C., et al.: Toxicol. Sci., 126, 525 (2012); Kosykhova, L., et al.: Pharm. Chem., 34, 525 (2000)

Formula: C₂H₆Cl₂NOP

Color and Shape: Colourless To Off-White

Molecular weight: 161.96

Ref: TR-D440125

N,N-Dimethylphosphoramidodichloridate

CAS: 677-43-0

Formula: C₂H₆Cl₂NOP

Color and Shape: Solid

Molecular weight: 161.9549

Ref: IN-DA003SLK