CAS 67724-08-7

Spiramycin, compd. with 4,4′-methylenebis[3-hydroxy-2-naphthalenecarboxylic acid]

Description:

Spiramycin, a macrolide antibiotic, is derived from the bacterium Streptomyces ambofaciens and is primarily used for its antibacterial properties, particularly against Gram-positive bacteria and certain protozoa. The compound associated with it, 4,4′-methylenebis[3-hydroxy-2-naphthalenecarboxylic acid], suggests a complex structure that may enhance its pharmacological activity. Spiramycin exhibits characteristics typical of macrolides, including a large lactone ring and a unique sugar moiety, which contribute to its mechanism of action by inhibiting bacterial protein synthesis. It is often administered in the treatment of respiratory infections, skin infections, and certain dental infections. The compound's solubility, stability, and bioavailability are influenced by its structural components, which can affect its therapeutic efficacy. Additionally, Spiramycin has been noted for its relatively low toxicity profile, making it a preferred choice in specific patient populations, including pregnant women. Overall, the combination of Spiramycin with 4,4′-methylenebis[3-hydroxy-2-naphthalenecarboxylic acid] may enhance its therapeutic potential, although further studies would be necessary to fully elucidate the implications of this combination.

Formula: C₂₃H₁₆O₆·xUnspecified

InChI: InChI=1/C43H74N2O14.C23H16O6/c1-24-21-29(19-20-46)39(59-42-37(49)36(45(9)10)38(27(4)56-42)58-35-23-43(6,51)41(50)28(5)55-35)40(52-11)31(47)22-33(48)53-25(2)15-13-12-14-16-32(24)57-34-18-17-30(44(7)8)26(3)54-34;24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29/h12-14,16,20,24-32,34-42,47,49-51H,15,17-19,21-23H2,1-11H3;1-10,24-25H,11H2,(H,26,27)(H,28,29)/b13-12+,16-14+;/t24-,25-,26-,27-,28+,29+,30+,31-,32+,34-,35+,36-,37-,38-,39+,40+,41+,42+,43-;/m1./s1

Synonyms:

• 2-Naphthalenecarboxylic acid, 4,4'-methylenebis(3-hydroxy-, compd. with spiramycin
• 4,4'-methanediylbis(3-hydroxynaphthalene-2-carboxylic acid) - [(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-{[(2S,3R,4R,5S,6R)-5-{[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-10-{[(2S,5S,6R)-5-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl]oxy}-4-hydroxy-5-methoxy-9,16-dimethyl-2-oxooxacyclohexadeca-11,13-dien-7-yl]acetaldehyde (1:1) (non-preferred name)
• Spiramycin embonate
• Spiramycin, compd. with 4,4′-methylenebis[3-hydroxy-2-naphthalenecarboxylic acid]
• Spiramycin, compd. with 4,4'-methylenebis(3-hydroxy-2-naphthalenecarboxylic acid)

Spiramycin embonate

CAS: 67724-08-7

Formula: C₆₆H₉₀N₂O₂₀

Molecular weight: 1231.42

Ref: 7W-GP0453

Spiramycin Embonate

Controlled Product

CAS: 67724-08-7

Applications Spiramycin Embonate is an antibiotic that is used in biological studies in the role of multidrug resistance of Strenotrophomonas maltophilia.
References Huang, Y., et al.: J. Antimicrob. Chemother., 68, 1987 (2013); Poole, K., et al.: Mol. Microbiol., 21, 713 (1996)

Formula: C₆₆H₉₀N₂O₂₀

Color and Shape: Neat

Molecular weight: 1231.42

Ref: TR-S682370