CAS 677331-12-3

iCRT 14

CAS: 677331-12-3

Formula: C₂₁H₁₇N₃O₂S

Purity: 99%

Color and Shape: Solid

Molecular weight: 375.4436

Ref: IN-DA00FC01

iCRT 14

CAS: 677331-12-3

iCRT 14

Purity: ≥98%

Molecular weight: 375.44g/mol

Ref: 54-BUP10083

iCRT14

CAS: 677331-12-3

Formula: C₂₁H₁₇N₃O₂S

Molecular weight: 375.44

Ref: 7W-GL1215

iCRT14

CAS: 677331-12-3

Formula: C₂₁H₁₇N₃O₂S

Molecular weight: 375.45

Ref: 4Z-I-113001

iCRT 14

CAS: 677331-12-3

iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).

Formula: C₂₁H₁₇N₃O₂S

Purity: 99.8% - 99.97%

Color and Shape: Solid

Molecular weight: 375.44

Ref: TM-T4486

iCRT-14

Controlled Product

CAS: 677331-12-3

Applications A potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Studies suggest that it may directly influence the interaction between β-catenin and TCF4. It induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines.
References Gonsalves, F.C. et al.: Proc. Natl. Acad. Sci. USA, 108, 5954 (2011); Watanabe, K. et al.: Proc. Natl. Acad. Sci. USA, 108, 5929 (2011);

Formula: C₂₁H₁₇N₃O₂S

Color and Shape: Neat

Molecular weight: 375.44

Ref: TR-I163900