CAS 6775-78-6

6-Chloroimidazo[1,2-b]pyridazine

Description:

6-Chloroimidazo[1,2-b]pyridazine is a heterocyclic compound characterized by its fused imidazole and pyridazine rings, with a chlorine substituent at the 6-position of the imidazole ring. This compound typically exhibits a pale yellow to off-white crystalline appearance. It is known for its potential biological activity, making it of interest in medicinal chemistry and drug development. The presence of the chlorine atom can influence its reactivity and solubility, often enhancing its pharmacological properties. 6-Chloroimidazo[1,2-b]pyridazine may participate in various chemical reactions, including nucleophilic substitutions and electrophilic aromatic substitutions, due to the electron-withdrawing nature of the chlorine atom. Its structural features contribute to its ability to interact with biological targets, which may include enzymes or receptors, thereby influencing cellular processes. As with many heterocycles, it may also exhibit unique spectral properties, making it amenable to characterization through techniques such as NMR and mass spectrometry. Overall, this compound represents a significant class of chemical entities with diverse applications in research and industry.

Formula: C₆H₄ClN₃

InChI: InChI=1/C6H4ClN3/c7-5-1-2-6-8-3-4-10(6)9-5/h1-4H

SMILES: c1cc2nccn2nc1Cl

Synonyms:

• 6-Chloroimidazo[2,1-f]pyridazine

6-Chloroimidazo[1,2-b]pyridazine

CAS: 6775-78-6

Formula: C₆H₄ClN₃

Purity: >98.0%(GC)(T)

Color and Shape: White to Gray to Brown powder to crystal

Molecular weight: 153.57

Ref: 3B-C3127

6-chloroimidazo[1,2-b]pyridazine

CAS: 6775-78-6

Formula: C₆H₄ClN₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 153.5691

Ref: IN-DA003N6I

6-Chloroimidazo(2,1-f)pyridazine

CAS: 6775-78-6

Ref: 7W-GK5433

6-Chloroimidazo[1,2-b]pyridazine

CAS: 6775-78-6

6-Chloroimidazo[1,2-b]pyridazine

Formula: C₆H₄ClN₃

Purity: 97%

Color and Shape: faint brown powder

Molecular weight: 153.57g/mol

Ref: 54-OR3292

6-Chloro-imidazo[1,2-b]pyridazine

CAS: 6775-78-6

6-Chloro-imidazo[1,2-b]pyridazine (6CI) is a potent inhibitor of the VEGF pathway. It inhibits the production of TNF-α and other inflammatory mediators by targeting the tumor necrosis factor receptor type 1 (TNFR1). 6CI has been shown to inhibit factor receptor activation in vitro, suggesting that it may also have an inhibitory effect on other receptors. These results suggest that 6CI can be used to treat inflammatory diseases such as rheumatoid arthritis.
6CI has been shown to bind to various halides, which may be due to the presence of hydrogen bonds. The molecular modeling studies show that the hydrogen bond stabilizes the binding between 6CI and TNFR1 and prevents this interaction from occurring with its natural ligand, VEGF.

Formula: C₆H₄ClN₃

Purity: Min. 95%

Color and Shape: White to off white crystalline powder

Molecular weight: 153.57 g/mol

Ref: 3D-FC11286

6-Chloroimidazo[1,2-b]pyridazine

CAS: 6775-78-6

Formula: C₆H₄ClN₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 153.57

Ref: 10-F049133