CAS 67812-42-4

(+/-)-verapamil

Description:

(+/-)-Verapamil is a calcium channel blocker primarily used in the treatment of hypertension, angina, and certain arrhythmias. It is a racemic mixture, meaning it contains equal parts of two enantiomers, which can exhibit different pharmacological effects. The substance works by inhibiting the influx of calcium ions through L-type calcium channels in cardiac and smooth muscle cells, leading to vasodilation and decreased heart rate. This action helps to reduce blood pressure and alleviate chest pain. (+/-)-Verapamil is characterized by its complex structure, which includes a phenylalkylamine backbone, and it is typically administered in oral or intravenous forms. The compound has a moderate solubility in water and is metabolized primarily in the liver, with a significant first-pass effect. Side effects may include hypotension, bradycardia, and gastrointestinal disturbances. Due to its interactions with other medications, careful consideration is necessary when prescribing verapamil, particularly in patients taking other cardiovascular drugs.

Formula: C₂₆H₃₇ClN₂O₄

InChI: InChI=1/C26H36N2O4.ClH/c1-19(2)26(18-27,21-9-11-23(30-4)25(17-21)32-6)13-7-14-28-15-12-20-8-10-22(29-3)24(16-20)31-5;/h8-11,16-17,19,28H,7,12-15H2,1-6H3;1H

SMILES: CC(C)C(CCCNCCc1ccc(c(c1)OC)OC)(C#N)c1ccc(c(c1)OC)OC.Cl

Synonyms:

• Benzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)amino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-, monohydrochloride
• (+/-)-VERAPAMIL, NOR-METHYL-, HYDROCHLORIDE
• (+-)-VERAPAMIL HYDROCHLORIDE, NOR-METHYL (NORVERAPAMIL HYDROCH
• NORVERAPAMIL HCL
• a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile
• NORVERAPAMIL HYDROCHLORIDE
• a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitril
• NorverapaMil HCl (N-DesMethyl VerapaMil HCl)
• α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)- benzeneacetonitrile
• n-nor-(±)-verapamil hydrochloride
• (±)-Norverapamill hydrochloride solution

Norverapamil hydrochloride

CAS: 67812-42-4

Norverapamil HCl, a Verapamil metabolite, blocks L-type calcium channels and inhibits P-gp function.

Formula: C₂₆H₃₇ClN₂O₄

Purity: 99.47%

Color and Shape: Solid

Molecular weight: 477.04

Ref: TM-T16339

Norverapamil, Hydrochloride

CAS: 67812-42-4

Formula: C₂₆H₃₇ClN₂O₄

Purity: 99.3877%

Color and Shape: Solid

Molecular weight: 477.0360

Ref: IN-DA00634Y

Norverapamil hydrochloride

CAS: 67812-42-4

Norverapamil hydrochloride

Purity: ≥98%

Molecular weight: 477.04g/mol

Ref: 54-BUP09438

(±)-Norverapamil hydrochloride

CAS: 67812-42-4

Formula: C₂₆H₃₆N₂O₄·HCl

Molecular weight: 477.04

Ref: 7W-GL3469

Verapamil EP Impurity J HCl (N-Desmethyl Verapamil HCl, Norverapamil HCl)

CAS: 67812-42-4

Formula: C₂₆H₃₆N₂O₄·HCl

Color and Shape: Pale Yellow Solid

Molecular weight: 440.58 36.46

Ref: 4Z-V-041

Nor Verapamil Hydrochloride

CAS: 67812-42-4

Impurity Verapamil EP Impurity J HCl
Applications Nor Verapamil Hydrochloride (Verapamil EP Impurity J HCl) is a metabolite of Verapamil.
References Mutlib, A.E., et al.: The Journal of Pharm. & Exp. Therapeutics, 252, 2, 593 (1989)

Formula: C₂₆H₃₇ClN₂O₄

Color and Shape: White

Molecular weight: 477.04

Ref: TR-N877500

Norverapamil (hydrochloride)

CAS: 67812-42-4

Purity: 98%

Molecular weight: 477.04

Ref: 10-F987724

2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethylamino]-2-propan-2-ylpentanenitrile hydrochloride

CAS: 67812-42-4

2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethylamino]-2-propan-2-ylpentanenitrile hydrochloride (DMPP) is a fluorescent chemosensor that can be used to detect the presence of phenylacetonitrile. It has been shown to have a linear response to phenylacetonitrile concentrations in rat plasma and also reacts with other compounds containing nitrogen atoms. The sensor was tested for its ability to react with drugs such as anti-tumor agents and showed strong regression correlation coefficients. This sensor has the potential to be used in pharmacokinetic studies because it can be detected by a variety of chromatographic techniques.

Formula: C₂₆H₃₆N₂O₄·HCl

Purity: Min. 95%

Molecular weight: 477.04 g/mol

Ref: 3D-ID26420