CAS 67914-61-8

Deacetylketoconazole

Description:

Deacetylketoconazole is a synthetic antifungal agent derived from ketoconazole, primarily used in the treatment of various fungal infections. It belongs to the class of imidazole derivatives and exhibits broad-spectrum antifungal activity by inhibiting the synthesis of ergosterol, a vital component of fungal cell membranes. This compound is characterized by its ability to disrupt fungal growth and reproduction, making it effective against a range of dermatophytes and yeast infections. Deacetylketoconazole is typically administered topically or orally, depending on the specific condition being treated. Its pharmacokinetics involve absorption, distribution, metabolism, and excretion, which can vary based on the formulation and route of administration. While generally well-tolerated, potential side effects may include gastrointestinal disturbances and liver enzyme alterations. As with any antifungal treatment, resistance can develop, necessitating careful monitoring and potential combination therapy. Overall, deacetylketoconazole represents a valuable option in the antifungal arsenal, particularly for resistant fungal strains.

Formula: C₂₄H₂₆Cl₂N₄O₃

InChI: InChI=1/C24H26Cl2N4O3/c25-18-1-6-22(23(26)13-18)24(16-29-10-7-28-17-29)32-15-21(33-24)14-31-20-4-2-19(3-5-20)30-11-8-27-9-12-30/h1-7,10,13,17,21,27H,8-9,11-12,14-16H2/t21-,24-/s2

InChI key: InChIKey=LOUXSEJZCPKWAX-DCJNBRHWNA-N

SMILES: C([C@]1(O[C@@H](COC2=CC=C(C=C2)N3CCNCC3)CO1)C4=C(Cl)C=C(Cl)C=C4)N5C=CN=C5

Synonyms:

• 1-(4-{[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine
• 1-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine
• Deacetylketoconazole
• Deacylketoconazole
• N-Deacetylketoconazole
• Piperazine, 1-(4-((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-, cis-
• Piperazine, 1-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-, rel-
• R 39519
• rel-1-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine
• cis-1-(4-((2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine

Ketoconazole Impurity D

CAS: 67914-61-8

Formula: C₂₄H₂₆Cl₂N₄O₃

Purity: 95%

Molecular weight: 489.39

Ref: 3W-CS-P-00436

Ketoconazole impurity standard

CAS: 65277-42-1, 67914-61-8

Ketoconazole impurity standard

Color and Shape: Off-White

Ref: 47-1170

Ketoconazole EP Impurity D

CAS: 67914-61-8

Ketoconazole EP Impurity D

Molecular weight: 489.4g/mol

Ref: 54-BI12154

Ketoconazole EP Impurity D (Ketoconazole Metabolite (M14))

CAS: 67914-61-8

Formula: C₂₄H₂₆Cl₂N₄O₃

Color and Shape: White To Off-White Solid

Molecular weight: 489.40

Ref: 4Z-K-016

Deacylketoconazole

CAS: 67914-61-8

Deacylketoconazole

Purity: ≥98%

Molecular weight: 489.39g/mol

Ref: 54-BUP06572

Ketoconazole EP Impurity D

Controlled Product

CAS: 67914-61-8

Color and Shape: Off-White

Ref: 86-MM0145.04

Ketoconazole Impurity 43

CAS: 67914-61-8

Formula: C₁₈H₁₆Cl₂O₄

Color and Shape: White To Off-White Solid

Molecular weight: 367.22

Ref: 4Z-K-0165

Ketoconazole EP Impurity D

CAS: 67914-61-8

Formula: C₂₄H₂₆Cl₂N₄O₃

Molecular weight: 489.40

Ref: ST-EA-CP-K2004

Deacetyl Ketoconazole

Controlled Product

CAS: 67914-61-8

Impurity Ketoconazole EP Impurity D
Applications Deacetyl Ketoconazole (Ketoconazole EP Impurity D) is a Ketoconazole derivative.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Formula: C₂₄H₂₆Cl₂N₄O₃

Color and Shape: Off-White

Molecular weight: 489.39

Ref: TR-D198955

Deacetyl ketoconazole

CAS: 67914-61-8

Deacetyl ketoconazole is a synthetic molecule that inhibits the synthesis of cholesterol and triglycerides by blocking the production of acetyl-CoA. It also has an anti-inflammatory effect, inhibiting the release of corticotropin-releasing hormone and reducing uptake of triglycerides from the bloodstream. Deacetyl ketoconazole is used for the treatment of depression, insulin resistance, and dyslipidemia. The natural form of ketoconazole is racemic, containing equal amounts of enantiomers (R and S). Deacetyl ketoconazole consists only of the S enantiomer, which has been shown to be more potent than racemic ketoconazole in animal models. This drug is synthesized by reacting piperazine with 3-hydroxybenzaldehyde in a two step process involving oxidation followed by reduction.

Formula: C₂₄H₂₆Cl₂N₄O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 489.39 g/mol

Ref: 3D-FD20827

Deacylketoconazole

CAS: 67914-61-8

Deacylketoconazole (Deacyl ketoconazole) is a Ketoconazole derivative and is also an antifungal agent.

Formula: C₂₄H₂₆Cl₂N₄O₃

Purity: 98.35%

Color and Shape: Solid

Molecular weight: 489.39

Ref: TM-T21022