CAS 67915-31-5

Terconazole

Description:

Terconazole is an antifungal agent primarily used in the treatment of vaginal yeast infections caused by Candida species. It belongs to the class of triazole antifungals, which function by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, thereby disrupting their integrity and leading to cell death. Terconazole is typically administered as a topical cream or vaginal suppository, allowing for localized treatment with minimal systemic absorption. The substance is characterized by its relatively low solubility in water but is soluble in organic solvents, which aids in its formulation. Terconazole exhibits a broad spectrum of activity against various fungi, particularly Candida albicans. Its pharmacokinetics indicate a prolonged duration of action, making it effective with fewer doses. Side effects are generally mild and may include local irritation or allergic reactions. Overall, terconazole is a valuable option in antifungal therapy, particularly for patients seeking localized treatment for vaginal infections.

Formula: C₂₆H₃₁Cl₂N₅O₃

InChI: InChI=1/C26H31Cl2N5O3/c1-19(2)31-9-11-32(12-10-31)21-4-6-22(7-5-21)34-14-23-15-35-26(36-23,16-33-18-29-17-30-33)24-8-3-20(27)13-25(24)28/h3-8,13,17-19,23H,9-12,14-16H2,1-2H3/t23-,26-/s2

InChI key: InChIKey=BLSQLHNBWJLIBQ-MKNUCDGGNA-N

SMILES: C([C@]1(O[C@@H](COC2=CC=C(C=C2)N3CCN(C(C)C)CC3)CO1)C4=C(Cl)C=C(Cl)C=C4)N5C=NC=N5

Synonyms:

• (.+-.)-Terconazole
• Fungistat
• Gyno-Terazol
• Nsc 331942
• Piperazine, 1-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(1-methylethyl)-, cis-
• R 42470
• Terazol
• Terazol Cream & Suppositories
• Terconazol
• Tercospor
• Termayazole
• Triaconazole
• rel-1-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(1-methylethyl)piperazine
• 1-(4-{[(4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)-4-(propan-2-yl)piperazine
• Terconagole
• 1-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)-4-(propan-2-yl)piperazine
• TERCONAZOLE USP(CRM STANDARD)
• 1-(4-{[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)-4-(propan-2-yl)piperazine
• 1-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-propan-2-yl-piperazine
• TERCONAZOLE EPT(CRM STANDARD)
• Piperazine, 1-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(1-methylethyl)-, rel-

TERCONAZOLE CRS

CAS: 67915-31-5

TERCONAZOLE CRS

Ref: 41-T0060000

Terconazole

CAS: 67915-31-5

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₂₆H₃₁Cl₂N₅O₃

Color and Shape: White Off-White Powder

Molecular weight: 531.1804

Ref: 45-1643703

Piperazine,1-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(1-methylethyl)-, rel-

CAS: 67915-31-5

Formula: C₂₆H₃₁Cl₂N₅O₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 532.4620

Ref: IN-DA00IBRL

Terconazole

CAS: 67915-31-5

Formula: C₂₆H₃₁Cl₂N₅O₃

Color and Shape: White To Off-White Solid

Molecular weight: 532.47

Ref: 4Z-T-142009

Terconazole

CAS: 67915-31-5

Formula: C₂₆H₃₁Cl₂N₅O₃

Molecular weight: 532.46

Ref: 7W-GP4833

1-(4-(((2R,4S)-2-((1H-1,2,4-Triazol-1-Yl)Methyl)-2-(2,4-Dichlorophenyl)-1,3-Dioxolan-4-Yl)Methoxy)Phenyl)-4-Isopropylpiperazine

CAS: 67915-31-5

1-(4-(((2R,4S)-2-((1H-1,2,4-Triazol-1-Yl)Methyl)-2-(2,4-Dichlorophenyl)-1,3-Dioxolan-4-Yl)Methoxy)Phenyl)-4-Isopropylpiperazine

Purity: 97%

Molecular weight: 532.46g/mol

Ref: 54-OR1025957

Terconazole

CAS: 67915-31-5

Terconazole

Purity: ≥98%

Molecular weight: 532.46g/mol

Ref: 54-BUP13962

Terconazole

Controlled Product

CAS: 67915-31-5

Formula: C₂₆H₃₁Cl₂N₅O₃

Color and Shape: Neat

Molecular weight: 532.46

Ref: 04-C17320500

Terconazole

Controlled Product

CAS: 67915-31-5

Formula: C₂₆H₃₁Cl₂N₅O₃

Color and Shape: Neat

Molecular weight: 532.46

Ref: 86-MM1286.00

Terconazole

CAS: 67915-31-5

Terconazole, a triazole antifungal, disrupts fungal cell walls by inhibiting ergosterol synthesis, active against Candida.

Formula: C₂₆H₃₁Cl₂N₅O₃

Purity: 98% - 99.60%

Color and Shape: Solid

Molecular weight: 532.46

Ref: TM-T2213

Terconazole-d8

CAS: 67915-31-5

Formula: C₂₆H₂₃D₈Cl₂N₅O₃

Molecular weight: 540.51

Ref: 4Z-T-142010

Terconazole

CAS: 67915-31-5

Terconazole is an azole antifungal agent with action on fungal cell membranes by inhibiting ergosterol biosynthesis and is used for treating vaginal yeast infections.

Formula: C₂₆H₃₁Cl₂N₅O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 532.46 g/mol

Ref: 3D-FT35141

Terconazole

CAS: 67915-31-5

Formula: C₂₆H₃₁Cl₂N₅O₃

Purity: 97%

Molecular weight: 532.47

Ref: 10-F547226

Terconazole

Controlled Product

CAS: 67915-31-5

Applications Terconazole belongs to a new chemical class of antifungal agents, the triazoles. Terconazole has a far greater selectively for yeast cytochrome P-450 than for mammalian microsomal cytochrome P-450 and is used as topical treatment of mycotic vaginitis. Terconazole may also be used in vitro as a potent antifungal agent to prevent the morphogenetic transformation of yeast into (pseudo-)mycelium form of Candida albicans.
References Cauwenbergh, G., Vanden Bossch H.: J. Reprod. Med., 34, 588 (1989); Del Palacio-Hernanz, A., et. al.: Chemioterapia, 3, 192 (1984); Van Cutsem, J., et. al.: Chemotherapy, 29, 322 (1983);

Formula: C₂₆H₃₁Cl₂N₅O₃

Color and Shape: White To Off-White

Molecular weight: 532.46

Ref: TR-T110600

Terconazole-d8

Controlled Product

CAS: 67915-31-5

Formula: C₂₆D₈H₂₃Cl₂N₅O₃

Color and Shape: Neat

Molecular weight: 540.511

Ref: TR-T110602

Terconazole

CAS: 67915-31-5

Color and Shape: Neat

Ref: 61-FOR1286.00