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CAS 68-22-4

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Norethindrone

Description:
Norethindrone is a synthetic progestin, primarily used in hormonal contraceptives and hormone replacement therapy. It is characterized by its ability to mimic the natural hormone progesterone, thereby regulating various reproductive functions. Norethindrone is typically presented as a white to off-white crystalline powder, with a molecular formula of C20H26O2 and a molecular weight of approximately 298.43 g/mol. It is relatively stable under normal conditions but should be stored in a cool, dry place away from light to maintain its efficacy. The substance is lipophilic, allowing it to be absorbed well in the body, and it has a moderate solubility in organic solvents. Norethindrone acts by inhibiting ovulation, altering the menstrual cycle, and thickening cervical mucus to prevent sperm penetration. Its pharmacological effects can lead to various side effects, including changes in menstrual patterns, weight gain, and mood alterations. Due to its hormonal activity, it is contraindicated in certain conditions, such as hormone-sensitive cancers and severe liver disease.
Formula:C20H26O2
InChI:InChI=1/C20H26O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,12,15-18,22H,4-11H2,2H3/t15-,16?,17?,18?,19-,20-/m0/s1
InChI key:InChIKey=VIKNJXKGJWUCNN-XGXHKTLJSA-N
SMILES:C[C@@]12[C@]([C@]3([C@](CC1)([C@@]4(C(CC3)=CC(=O)CC4)[H])[H])[H])(CC[C@]2(C#C)O)[H]
Synonyms:
  • (17Beta)-17-Ethynyl-17-Hydroxyestr-4-En-3-One
  • (17α)-17-Hydroxy-19-Norpregn-4-en-20-yn-3-one
  • (8Xi,9Xi,14Xi,17Beta)-17-Ethynyl-17-Hydroxyestr-4-En-3-One
  • 17-Alpha-Ethynyl-17-Beta-Hydroxyoestr-4-En-3-One
  • 17-Ethynyl-17-Hydroxyestr-4-En-3-One
  • 17-Hydroxy-19-nor-17α-pregn-4-en-20 yn-3-one
  • 17α-Ethinyl-17β-hydroxy-Δ4-estren-3-one
  • 17α-Ethinyl-17β-hydroxy-Δ<sup>4</sup>-estren-3-one
  • 17α-Ethinyl-19-nortestosterone
  • 17α-Ethinylestr-4-en-17β-ol-3-one
  • See more synonyms
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