CAS 68-23-5

Norethynodrel

Description:

Norethynodrel is a synthetic progestin, primarily used in hormonal contraceptives and hormone replacement therapy. It is characterized by its ability to mimic the effects of natural progesterone, thereby regulating various reproductive functions. The molecular formula of norethynodrel indicates that it contains carbon, hydrogen, and oxygen atoms, contributing to its steroidal structure. This compound is typically administered orally and is known for its effectiveness in preventing ovulation, altering the menstrual cycle, and providing endometrial protection. Norethynodrel exhibits moderate lipophilicity, which influences its absorption and distribution in the body. Its pharmacological profile includes potential side effects such as weight gain, mood changes, and alterations in menstrual patterns. Additionally, it is important to consider its contraindications and interactions with other medications. As with any hormonal treatment, careful monitoring and consultation with a healthcare provider are essential to ensure safe and effective use. Overall, norethynodrel plays a significant role in reproductive health management.

Formula: C₂₀H₂₆O₂

InChI: InChI=1S/C20H26O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,16-18,22H,4-12H2,2H3/t16-,17-,18+,19+,20+/m1/s1

InChI key: InChIKey=ICTXHFFSOAJUMG-SLHNCBLASA-N

SMILES: C[C@@]12[C@]([C@]3([C@](CC1)(C4=C(CC3)CC(=O)CC4)[H])[H])(CC[C@]2(C#C)O)[H]

Synonyms:

• (17Beta)-17-Ethynyl-17-Hydroxyestr-5(10)-En-3-One
• (17α)-17-Hydroxy-19-norpregn-5(10)-en-20-yn-3-one
• (8Xi,9Xi,14Xi,17Beta)-17-Ethynyl-17-Hydroxyestr-5(10)-En-3-One
• 13-Methyl-17-ethynyl-17-hydroxy-1,2,3,4,6,7,8,9,11,12,13,14,16,17-tetradecahydro-15H-cyclopenta[a]phenanthren-3-one
• 17-Beta-Hydroxy-19-Nor-17-Alpha-Pregn-5(10)-En-20-Yn-3-One
• 17-Ethynyl-17-Hydroxyestr-5(10)-En-3-One
• 17-Hydroxy-19-nor-17α-pregn-5(10)-en-20-yn-3-one
• 17α-Ethinyl-17β-hydroxy-Δ⁵(¹⁰)-estren-3-one
• 17α-Ethynyl-17-hydroxy-5(10)-estren-3-one
• 17α-Ethynyl-17β-hydroxy-5(10)-estrene-3-one
• 17α-Ethynyl-17β-hydroxy-Δ⁵⁽¹⁰⁾-estren-3-one
• 17α-Ethynylestr-5(10)-ene-17β-ol-3-one
• 17α-Ethynylestra-5(10)-ene-17β-ol-3-one
• 17β-Hydroxy-19-nor-17α-pregn-5(10)-en-20-yn-3-one
• 19-Nor-17α-pregn-5(10)-en-20-yn-3-one, 17-hydroxy-
• 19-Norpregn-5(10)-en-20-yn-3-one, 17-hydroxy-, (17α)-
• 3-Oxo-17β-hydroxy-17α-ethynyl-5(10)-estrene
• Enidrel
• NSC 15432
• Norethinodrel
• Noretynodrel
• Sc 4642

Norethynodrel

CAS: 68-23-5

Color and Shape: Neat

Ref: 61-FOR1170.00

Norethynodrel

CAS: 68-23-5

Norethynodrel

Purity: ≥95%

Molecular weight: 298.42g/mol

Ref: 54-OR1075454

Norethynodrel

CAS: 68-23-5

Formula: C₂₀H₂₆O₂

Color and Shape: White To Off-White Solid

Molecular weight: 298.43

Ref: 4Z-N-511

Norethynodrel

CAS: 68-23-5

Norethynodrel, a synthetic hormone, mimics progesterone, treats uterine bleeding/endometriosis, and is used with mestranol as a contraceptive.

Formula: C₂₀H₂₆O₂

Purity: 98%

Color and Shape: Crystals From Aqueous Methanol Solid

Molecular weight: 298.42

Ref: TM-T0171

Norethynodrel

CAS: 68-23-5

Impurity Norethindrone EP Impurity D
Applications Norethynodrel (Norethindrone EP Impurity D) is a progestin used in Enovid, an oral contraceptive, also used in the treatment of endometriosis and hypermenorrhea.
References Palmer K., et al.: J. Pharmacol. Exp. Ther., 167, 207 (1969), Liu, L., et al.: Endocrinology., 151, 5782 (2010), Sonneveld, E., et al.: Toxicol. in Vitro, 25, 545 (2011)

Formula: C₂₀H₂₆O₂

Purity: >90%

Color and Shape: Off-White

Molecular weight: 298.42

Ref: TR-N676020

Norethynodrel

Controlled Product

CAS: 68-23-5

Norethynodrel is a progestin that is used in combination with other drugs to prevent pregnancy. It works by inhibiting ovulation, thickening cervical mucus to inhibit sperm penetration, and altering the uterine lining. This drug has been shown to have carcinogenic potential in animal models and can lead to myocardial infarcts. Norethynodrel binds competitively to the receptor site of estradiol benzoate or estradiol, preventing it from binding and activating the estrogen-dependent response. This mechanism of action also inhibits the enzyme activity of 17β-hydroxysteroid dehydrogenase type II (17βHSD2) and reductase activity of 3βHSD, which are involved in hormone synthesis. The lack of these two enzymes leads to an accumulation of estrogens, which may contribute to carcinogenic effects.

Formula: C₂₀H₂₆O₂

Purity: Min. 96 Area-%

Color and Shape: Powder

Molecular weight: 298.42 g/mol

Ref: 3D-FN26448

Norethynodrel

CAS: 68-23-5

Purity: 98%

Molecular weight: 298.4259949

Ref: 10-F600857

Norethindrone EP Impurity D

CAS: 68-23-5

Formula: C₂₀H₂₆O₂

Molecular weight: 298.43

Ref: ST-EA-CP-N51004