CAS 68-42-8

Tetrahydrocorticosterone

Description:

Tetrahydrocorticosterone (THC) is a steroid hormone that belongs to the class of corticosteroids, which are produced in the adrenal cortex. It is primarily involved in the regulation of various physiological processes, including metabolism, immune response, and stress response. THC is characterized by its structure, which includes a steroid nucleus with four fused carbon rings. It is a relatively hydrophobic compound, which influences its solubility and transport in biological systems. The hormone exhibits anti-inflammatory properties and plays a role in the body's response to stress by modulating glucose metabolism and electrolyte balance. In terms of its biological activity, THC can bind to specific receptors, influencing gene expression and cellular functions. It is important in research related to adrenal function and has implications in understanding various disorders related to adrenal insufficiency and stress-related conditions. Due to its hormonal nature, the regulation of THC levels in the body is crucial for maintaining homeostasis.

Formula: C₂₁H₃₄O₄

InChI: InChI=1/C21H34O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h12-17,19,22-24H,3-11H2,1-2H3/t12-,13-,14+,15+,16-,17+,19-,20+,21+/m1/s1

InChI key: InChIKey=RHQQHZQUAMFINJ-DTDWNVJFSA-N

SMILES: C[C@@]12[C@@]3([C@]([C@]4([C@](C)(C[C@@H]3O)[C@@H](C(CO)=O)CC4)[H])(CC[C@@]1(C[C@H](O)CC2)[H])[H])[H]

Synonyms:

• (3Alpha,5Beta,11Beta)-3,11,21-Trihydroxypregnan-20-One
• (3α,5β,11β)-3,11,21-Trihydroxypregnan-20-one
• 3alpha,11beta,21-Trihydroxy-5beta-pregnan-20-one
• 3α,11β,21-Trihydroxy-5β-pregnan-20-one
• 3α,5β-Tetrahydrocorticosterone
• 5β-Pregnan-20-one, 3α,11β,21-trihydroxy-
• 5β-Pregnane-3α,11β,21-triol-20-one
• Corticosterone, tetrahydro-
• Pregnan-20-one, 3,11,21-trihydroxy-, (3α,5β,11β)-
• Tetrahydrocorticosterone
• (6R)-5,6,7,8-TETRAHYDRO-L-BIOPTERIN 2HCL
• Tetrahydrocorticosterone (solution)
• 5BETA-PREGNANE-3A,11BETA,21-TRIOL-20-ONE
• 3-ALPHA,11-BETA,21-TRIHYDROXY-5-BETA-PREGNAN-20-ONE
• 5-BETA-PREGNANE-3-ALPHA,11-BETA,21-TRIOL-20-ONE
• THB
• 1-[(3R,5R,8S,9S,10S,11S,13S,14S,17S)-3,11-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-hydroxy-ethanone
• 1-[(3R,5R,8S,9S,10S,11S,13S,14S,17S)-3,11-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-hydroxyethanone
• TETRAHYDRO COMPOUND 'B'
• TH 'B'

Tetrahydrocorticosterone

CAS: 68-42-8

Formula: C₂₁H₃₄O₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 350.4923

Ref: IN-DA00FA58

5β-Pregnan-3α, 11β,21-triol-20-one-17α,21,21-d3 (Tetrahydrocorticosterone)

CAS: 68-42-8

Purity: 98 atom % D

Molecular weight: 353.51

Ref: 3U-D7804

Tetrahydrocorticosterone

CAS: 68-42-8

Formula: C₂₁H₃₄O₄

Molecular weight: 350.50

Ref: 4Z-C-10412

Tetrahydrocorticosterone

CAS: 68-42-8

Applications Tetrahydrocorticosterone is a urinary steroid metabolite that decreases in postmenopausal women with osteoporosis. Tetrahydrocorticosterone is a potential biomarker of pathol. adrenal function.
References Poor, V., et. al.: Chromatographia, 60, S165 (2004); Kotlowska, A., et. al.: J. Chromatogr. B, 879, 359 (2011)

Formula: C₂₁H₃₄O₄

Color and Shape: Neat

Molecular weight: 350.49

Ref: TR-T293160

Tetrahydrocorticosterone

Controlled Product

CAS: 68-42-8

Tetrahydrocorticosterone is a hormone produced by the adrenal glands that regulates the metabolism of carbohydrates, proteins, and fats. It also has other biological effects such as inhibition of cyclase activity and production of malonic acid. Tetrahydrocorticosterone can be used to measure cortisol concentration in blood serum or urine samples. The detection sensitivity for this compound is 5-10 ng/mL. This hormone is found in high concentrations in adrenocortical carcinoma, which may be due to its ability to inhibit cyclase activity. Tetrahydrocorticosterone has been shown to have an effect on glomerular filtration rate and body mass index, which may be due to its ability to promote protein synthesis.

Formula: C₂₁H₃₄O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 350.49 g/mol

Ref: 3D-FT65181

Tetrahydrocorticosterone

CAS: 68-42-8

THB is a glucocorticoid with anti-inflammatory effects, acting on GC receptors; its isomers vary between male and female rat brains.

Formula: C₂₁H₃₄O₄

Color and Shape: Solid

Molecular weight: 350.49

Ref: TM-T68877