CAS 68-88-2

(±)-Hydroxyzine

Description:

(±)-Hydroxyzine is a first-generation antihistamine with anxiolytic, sedative, and antiemetic properties. It is classified as a piperazine derivative and is commonly used to treat anxiety, allergies, and nausea. The compound exhibits a complex structure, featuring a diphenylmethane moiety and a piperazine ring, which contributes to its pharmacological effects. Hydroxyzine acts primarily as an antagonist of the H1 histamine receptor, leading to its sedative effects, while also possessing anticholinergic properties. It is typically administered in the form of its hydrochloride salt, which enhances its solubility and bioavailability. The substance is known for its relatively rapid onset of action and a duration of effect that can vary based on the route of administration. Side effects may include drowsiness, dry mouth, and dizziness, which are common among antihistamines. Due to its sedative properties, caution is advised when operating machinery or driving after taking hydroxyzine. Overall, (±)-Hydroxyzine is a versatile medication with a well-established profile in clinical use.

Formula: C₂₁H₂₇ClN₂O₂

InChI: InChI=1S/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2

InChI key: InChIKey=ZQDWXGKKHFNSQK-UHFFFAOYSA-N

SMILES: C(N1CCN(CCOCCO)CC1)(C2=CC=C(Cl)C=C2)C3=CC=CC=C3

Synonyms:

• 1-(p-Chloro-α-phenylbenzyl)-4-(2'-hydroxyethoxyethyl)-piperazine
• 1-(p-Chloro-α-phenylbenzyl)-4-[2-((2-hydroxyethoxy)ethyl)]piperazine
• 1-(p-Chlorobenzhydryl)-4-[2-(2-hydroxyethoxy)ethyl]diethylenediamine
• 1-(p-Chlorobenzhydryl)-4-[2-(2-hydroxyethoxy)ethyl]piperazine
• 1-(p-Chlorodiphenylmethyl)-4-[2-(2-hydroxyethoxy)ethyl]piperazine
• 2-(2-(4-(4-Chlorobenzhydryl)Piperazin-1-Yl)Ethoxy)Ethanol
• 2-(2-[4-[(4-Chlorophenyl)(phenyl)methyl]piperazin-1-yl]ethoxy)ethan-1-ol
• 2-[2-[4-(p-Chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]ethanol
• 2-[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]ethanol
• Ethanol, 2-[2-[4-(4-chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]-
• Ethanol, 2-[2-[4-(p-chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]-
• Ethanol, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-
• Hidroxizina
• Hydroxizine
• Hydroxyzin
• Hydroxyzyne
• Nsc 169188
• Tran-Q
• Tranquizine

Hydroxyzine

CAS: 68-88-2

Formula: C₂₁H₂₇ClN₂O₂

Purity: 95%

Color and Shape: Liquid

Molecular weight: 374.9043

Ref: IN-DA005NO2

2-(2-{4-[(4-Chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-ethoxy)-ethanol

CAS: 68-88-2

2-(2-{4-[(4-Chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-ethoxy)-ethanol

Purity: 95%

Molecular weight: 374.911g/mol

Ref: 54-OR97588

Hydroxyzine

CAS: 68-88-2

Hydroxyzine

Purity: ≥95%

Molecular weight: 374.9g/mol

Ref: 54-BUP16167

Hydroxyzine

CAS: 68-88-2

Hydroxyzine (Hydroxyzine free base) is an antagonist of histamine H1-receptor.

Formula: C₂₁H₂₇ClN₂O₂

Purity: 99.54% - ≥95%

Color and Shape: Oil Solid

Molecular weight: 374.9

Ref: TM-T20884

Hydroxyzine

Controlled Product

CAS: 68-88-2

Applications H1 receptor antagonist. Anxiolytic. Antihistaminic.
References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Tsau, J., et al.: Anal. Profiles Drug Subs., 7, 319 (1978)

Formula: C₂₁H₂₇ClN₂O₂

Color and Shape: Yellow

Molecular weight: 374.9

Ref: TR-H996495

2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol

CAS: 68-88-2

Purity: 95.0%

Molecular weight: 374.9100036621094

Ref: 10-F242510

Hydroxyzine

CAS: 68-88-2

Formula: C₂₁H₂₇ClN₂O₂

Molecular weight: 374.91

Ref: ST-EA-CP-H11000