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CAS 68-88-2

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(±)-Hydroxyzine

Description:
(±)-Hydroxyzine is a first-generation antihistamine with anxiolytic, sedative, and antiemetic properties. It is classified as a piperazine derivative and is commonly used to treat anxiety, allergies, and nausea. The compound exhibits a complex structure, featuring a diphenylmethane moiety and a piperazine ring, which contributes to its pharmacological effects. Hydroxyzine acts primarily as an antagonist of the H1 histamine receptor, leading to its sedative effects, while also possessing anticholinergic properties. It is typically administered in the form of its hydrochloride salt, which enhances its solubility and bioavailability. The substance is known for its relatively rapid onset of action and a duration of effect that can vary based on the route of administration. Side effects may include drowsiness, dry mouth, and dizziness, which are common among antihistamines. Due to its sedative properties, caution is advised when operating machinery or driving after taking hydroxyzine. Overall, (±)-Hydroxyzine is a versatile medication with a well-established profile in clinical use.
Formula:C21H27ClN2O2
InChI:InChI=1S/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2
InChI key:InChIKey=ZQDWXGKKHFNSQK-UHFFFAOYSA-N
SMILES:C(N1CCN(CCOCCO)CC1)(C2=CC=C(Cl)C=C2)C3=CC=CC=C3
Synonyms:
  • 1-(p-Chloro-α-phenylbenzyl)-4-(2'-hydroxyethoxyethyl)-piperazine
  • 1-(p-Chloro-α-phenylbenzyl)-4-[2-((2-hydroxyethoxy)ethyl)]piperazine
  • 1-(p-Chlorobenzhydryl)-4-[2-(2-hydroxyethoxy)ethyl]diethylenediamine
  • 1-(p-Chlorobenzhydryl)-4-[2-(2-hydroxyethoxy)ethyl]piperazine
  • 1-(p-Chlorodiphenylmethyl)-4-[2-(2-hydroxyethoxy)ethyl]piperazine
  • 2-(2-(4-(4-Chlorobenzhydryl)Piperazin-1-Yl)Ethoxy)Ethanol
  • 2-(2-[4-[(4-Chlorophenyl)(phenyl)methyl]piperazin-1-yl]ethoxy)ethan-1-ol
  • 2-[2-[4-(p-Chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]ethanol
  • 2-[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]ethanol
  • Ethanol, 2-[2-[4-(4-chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]-
  • See more synonyms
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