CAS 68-89-3

Dipyrone

Description:

Dipyrone, also known as metamizole, is a non-opioid analgesic and antipyretic agent commonly used for pain relief and fever reduction. It is classified as a pyrazolone derivative and is known for its potent analgesic properties. Dipyrone is typically administered in its sodium salt form, which enhances its solubility in water. The compound is characterized by its ability to inhibit prostaglandin synthesis, thereby reducing pain and inflammation. It is often used in clinical settings for severe pain management, particularly when other analgesics are ineffective. However, dipyrone has been associated with serious side effects, including agranulocytosis, a potentially life-threatening decrease in white blood cell count, which has led to its restricted use in some countries. The substance is generally well-absorbed when administered orally or intravenously, and its effects can be rapid, making it a valuable option in acute pain scenarios. Despite its efficacy, healthcare providers must weigh the benefits against the risks when considering dipyrone for patient treatment.

Formula: C₁₃H₁₆N₃NaO₄S

InChI: InChI=1/C13H19N3O4S.Na/c1-10-12(14(2)9-21(18,19)20)13(17)16(15(10)3)11-7-5-4-6-8-11;/h4-8,10,12H,9H2,1-3H3,(H,18,19,20);/q;+1/p-1/rC13H18N3NaO4S/c1-10-12(14(2)9-22(19,20)21-17)13(18)16(15(10)3)11-7-5-4-6-8-11/h4-8,10,12H,9H2,1-3H3

InChI key: InChIKey=CEOUXRNZHGKECQ-UHFFFAOYSA-N

SMILES: O=C1N(N(C)C(C)=C1N(CS(=O)(=O)O)C)C2=CC=CC=C2.[Na]

Synonyms:

• Algocalmin
• Algopyrin
• Amoloid HV
• Amoloid LV
• Anador
• Analgin
• Analgin DAB10
• Analgine
• Andolor
• Arpf
• Collatex A/RE
• Collatex Arm Extra
• CollatexA/RE Extra
• Conmel
• Diprofarn
• Dipyrone,hydrate
• Duckammon
• E 403
• Gifaril
• Kimica Algin NH
• Kimitsu Algin NH
• Lisador
• Manutex PC-MV
• Metamizol
• Metamizole
• Metamizole Sodium
• Metamizole sodium salt
• Metapyrin
• Methamizole sodium
• Methampyrone
• Methanesulfonic acid, (antipyrinylmethylamino)-, sodium salt
• Methanesulfonic acid, 1-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]-, sodium salt (1:1)
• Methanesulfonic acid, [(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]-, sodium salt
• Methylmelubrin
• Metilon
• Narone
• Natrium-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methansulfonat
• Neo-melubrine
• Noramidopyrine methanesulfonate sodium
• Noramidopyrine methanesulfonate sodium salt
• Noraminophenazone methanesulfonate sodium salt
• Noraminophenazone sodium mesylate
• Novalgetol
• Novalgin
• Novamidazophen
• Novaminophenazone
• Novaminsulfone
• Novaminsulfone sodium
• Novaminsulfonium
• Novaminsulfonum
• Noveltex
• Optalgin
• Pharmalgine
• Protamon S
• Pyralgine
• Pyretin
• Pyretin (pharmaceutical)
• Restriva
• Sodium ((2,3-Dihydro-1,5-Dimethyl-3-Oxo-2-Phenyl-1H-Pyrazol-4-Yl)Methylamino)Methanesulfonate
• Sodium (antipyrinylmethylamino)methanesulfonate
• Sodium 1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethanesulfonate
• Sodium [(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulphonate
• Sodium metamizole
• Sodium noramidopyrine methanesulfonate
• Sodium novaminsulfonate
• Sulpin
• Sulpyrin
• Sulpyrine
• [(1,5-Dimethyl-3-Oxo-2-Phenyl-Pyrazolidin-4-Yl)-Methyl-Amino]Methylsulfonyloxy Sodium
• [(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl)amino]methanesulfonate
• [(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulfonic acid sodium salt
• [(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-yl)methylamino]methanesulfonate de sodium
• [(2-fenil-2,3-dihidro-1,5-dimetil-3-oxo-1H-pirazol-4-il)metilamino]metanosulfonato de sodio
• sodium [(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl)amino]methanesulfonate
• sodium [(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl)amino]methanesulfonate hydrate (1:1:1)
• Dipyrone
• BENZALAGEN
• (antipyrinylmethylamino)-methanesulfonicacimonosodiumsalt
• SODIUM [(1,5-DIMETHYL-3-OXO-2-PHENYL-PYRAZOL-4-YL)-METHYL-AMINO]METHANESULFONATE
• 4-methylamino-1,5-dimethyl-2-phenyl-3-pyrazolonesodiummethanesulfonate
• (antipyrinylmethylamino)methanesulfonicacidsodiumsalt
• 1-phenyl-2,3-dimethylpyrazolone-(5)-4-methylaminomethanesulfonicacidsodium
• dipyron
• LABOTEST-BB LT00771955
• (antipyrinylmethylamino)-methanesulfonicacisodiumsalt
• DIPYRONE SODIUM
• 1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethanesulfonatesodium
• METAMIZOL SODIUM
• SODIUM DIPYRONE

Metamizole Sodium Salt

CAS: 68-89-3

Formula: C₁₃H₁₆N₃NaO₄S

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 333.34

Ref: 3B-M3060

Dipyrone

CAS: 68-89-3

Formula: C₁₃H₁₇N₃NaO₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 334.3465

Ref: IN-DA006FYJ

Metamizole sodium

CAS: 68-89-3

Metamizole sodium (Analgin) is a drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.

Formula: C₁₃H₁₆N₃NaO₄S

Purity: 99.52%

Color and Shape: White Or Almost White Crystal Powder

Molecular weight: 333.34

Ref: TM-T1191L

Metamizole Sodium Salt (Dipyrone)

CAS: 68-89-3

Formula: C₁₃H₁₆N₃O₄S·Na

Color and Shape: White To Off-White Solid

Molecular weight: 310.35 22.99

Ref: 4Z-M-531

Dipyrone

CAS: 68-89-3

Dipyrone

Purity: 98%

Molecular weight: 333.34g/mol

Ref: 54-OR1029314

Metamizole sodium

CAS: 68-89-3

Metamizole sodium

Purity: ≥98%

Molecular weight: 333.34g/mol

Ref: 54-BUP10835

Metamizol sodium

Controlled Product

CAS: 68-89-3

Formula: C₁₃H₁₆N₃O₄S·Na

Color and Shape: White

Molecular weight: 333.34

Ref: 04-C14942000

Dipyrone

Controlled Product

CAS: 68-89-3

Applications Dipyrone is a non-steroidal anti-inflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a relatively selective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX-1 and no activity against COX-2. Dipyrone blocks PGE2-induced hyperalgesia in several models. Neuroprotective & Neuroresearch Product.
References Reith, J., et al.: Lancet, 347, 422 (1996), Grau, A., et al.: J. Neurol. Sci., 171, 115 (1999), Schwarz, S., et al.: Neurology, 2000, 54, 354 (2000), Greer, D., et al.: Stroke, 39, 3029 (2008),

Formula: C₁₃H₁₆N₃O₄S·Na

Color and Shape: Neat

Molecular weight: 333.34

Ref: TR-D492860

Dipyrone-d3

Controlled Product

CAS: 68-89-3

Stability Hygroscopic
Applications Labelled Dipyrone. Dipyrone is a non-steroidal anti-inflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a relatively selective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX-1 and no activity against COX-2. Dipyrone blocks PGE2-induced hyperalgesia in several models.
References Reith, J. et al.: Lancet, 347, 422 (1996); Grau, A. et al.: J. Neurol. Sci., 171, 115 (1999); Schwarz, S. et al.: Neurology, 2000, 54, 354 (2000); Greer, D. et al.: Stroke, 39, 3029 (2008);

Formula: C₁₃H₁₃D₃N₃NaO₄S

Color and Shape: Off-White

Molecular weight: 336.36

Ref: TR-D492862

Dipyrone

CAS: 68-89-3

Dipyrone is an anti-inflammatory and analgesic drug that belongs to the group of non-steroidal anti-inflammatory drugs. It has been shown to inhibit the production of prostaglandins, which are involved in inflammation, by inhibiting cyclooxygenase. The polymerase chain reaction (PCR) method is a biochemical technique used to amplify a segment of DNA, typically for use as a genetic marker or for cloning a particular gene. A PCR assay can be used to detect the presence of bacterial DNA in a sample. Dipyrone has been shown to possess chemiluminescence activity, which is indicative of its ability to bind with DNA. This binding inhibits transcription and replication and may be responsible for the toxic effects on epidermal cells observed in animal studies. Dipyrone also has been shown to have anti-inflammatory activities through its inhibition of cyclooxygenase and its ability to inhibit neutrophil migration and function.

Formula: C₁₃H₁₆N₃NaO₄S

Purity: Min. 95%

Color and Shape: White Solid

Molecular weight: 333.34 g/mol

Ref: 3D-FD22539

Dipyrone Sodium Salt

CAS: 68-89-3

Formula: C₁₃H₁₆N₃O₄SNa

Molecular weight: 310.3 : 23.0

Ref: ST-EA-CP-A231001