CAS 68047-06-3

4-Hydroxytamoxifen

Description:

4-Hydroxytamoxifen is a selective estrogen receptor modulator (SERM) that is primarily known for its role in the treatment of estrogen receptor-positive breast cancer. It is a metabolite of tamoxifen, which is widely used in breast cancer therapy. The compound exhibits both estrogenic and anti-estrogenic properties, depending on the target tissue. Chemically, it features a hydroxyl group at the 4-position of the tamoxifen structure, which enhances its binding affinity to estrogen receptors. This modification contributes to its effectiveness in inhibiting the growth of estrogen-dependent tumors. 4-Hydroxytamoxifen is typically administered orally and is known for its relatively favorable pharmacokinetic profile, including good bioavailability. Its mechanism of action involves competitive inhibition of estrogen binding to its receptor, leading to a reduction in estrogen-mediated cellular proliferation. Additionally, it has been studied for its potential effects on other conditions influenced by estrogen, such as endometriosis. Overall, 4-Hydroxytamoxifen is a crucial compound in oncology, particularly in hormone-responsive breast cancer management.

Formula: C₂₆H₂₉NO₂

InChI: InChI=1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-

InChI key: InChIKey=TXUZVZSFRXZGTL-QPLCGJKRSA-N

SMILES: C(=C(/CC)\C1=CC=CC=C1)(\C2=CC=C(OCCN(C)C)C=C2)/C3=CC=C(O)C=C3

Synonyms:

• (Z)-4-Hydroxytamoxifen
• (Z)-4-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenylbut-1-en-1-yl]phenol
• 4-(1-{4-[2-(Dimethylamino)Ethoxy]Phenyl}-2-Phenylbut-1-En-1-Yl)Phenol
• 4-Hydroxy-(Z)-tamoxifen
• 4-[(1Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol
• 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol
• 4-{(1Z)-1-[{4-[2-(dimethylamino)ethoxy]phenyl}(phenyl)methylidene]propyl}phenol
• Hydroxytamoxifen
• Ici 79280
• Phenol, 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-
• Phenol, 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]-
• Phenol, 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]-, (Z)-
• trans-4-Hydroxytamoxifen

(Z)-4-Hydroxytamoxifen

CAS: 68047-06-3

Formula: C₂₆H₂₉NO₂

Purity: >95.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 387.52

Ref: 3B-H1693

4-Hydroxytamoxifen

CAS: 68047-06-3

Formula: C₂₆H₂₉NO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 387.5140

Ref: IN-DA00FBGH

4-Hydroxytamoxifen

CAS: 68047-06-3

4-Hydroxytamoxifen

Purity: ≥98%

Molecular weight: 387.51g/mol

Ref: 54-BUP10134

4-Hydroxytamoxifen

CAS: 68047-06-3

4-Hydroxytamoxifen

Purity: 97%

Molecular weight: 387.51g/mol

Ref: 54-OR1023891

4-Hydroxy Tamoxifen

CAS: 68047-06-3

Formula: C₂₆H₂₉NO₂

Color and Shape: White To Off-White Solid

Molecular weight: 387.53

Ref: 4Z-T-013

Tamoxifen-4-hydroxy

CAS: 68047-06-3

Color and Shape: White To Off-White

Ref: 04-C17137250

4-Hydroxytamoxifen

CAS: 68047-06-3

4-Hydroxytamoxifen (ICI 79280) is the active metabolite of Tamoxifen, an estrogen receptor modulator (SERM) with selective and oral potency.

Formula: C₂₆H₂₉NO₂

Purity: 99.37% - 99.93%

Color and Shape: Solid

Molecular weight: 387.51

Ref: TM-T4420

(Z)-4-Hydroxy Tamoxifen

CAS: 68047-06-3

Formula: C₂₆H₂₉NO₂

Color and Shape: White To Off-White

Molecular weight: 387.51

Ref: TR-H954725

(Z)-4-Hydroxytamoxifen

CAS: 68047-06-3

Molecular weight: 387.52301025390625

Ref: 10-F549792

(Z)-4-Hydroxytamoxifen

Controlled Product

CAS: 68047-06-3

Estrogen receptor antagonist; tamoxifen metabolite

Formula: C₂₆H₂₉NO₂

Purity: Min. 95%

Color and Shape: White/Off-White Solid

Molecular weight: 387.51 g/mol

Ref: 3D-FH24133