CAS 6805-41-0

Escin

Description:

Escin, also known as aescin, is a natural mixture of saponins derived from the seeds of the horse chestnut tree (Aesculus hippocastanum). It is primarily composed of two main components: α-escin and β-escin. Escin exhibits several notable characteristics, including its ability to enhance capillary permeability and reduce inflammation, making it useful in various medicinal applications, particularly in treating conditions related to venous insufficiency and edema. The substance has surfactant properties, which contribute to its effectiveness in stabilizing emulsions and foams. Additionally, escin has been studied for its potential antioxidant effects and its role in promoting microcirculation. In terms of solubility, escin is generally soluble in water and alcohol, but its solubility can vary depending on the specific formulation. Safety assessments indicate that escin is well-tolerated when used appropriately, although it may cause mild gastrointestinal disturbances in some individuals. Overall, escin is valued for its therapeutic properties and is commonly found in dietary supplements and topical formulations aimed at improving vascular health.

Formula: Unspecified

InChI: InChI=1/C55H86O24/c1-10-23(2)46(71)79-43-44(72-24(3)60)55(22-59)26(17-50(43,4)5)25-11-12-30-51(6)15-14-32(52(7,21-58)29(51)13-16-53(30,8)54(25,9)18-31(55)61)75-49-41(77-48-38(67)36(65)34(63)28(20-57)74-48)39(68)40(42(78-49)45(69)70)76-47-37(66)35(64)33(62)27(19-56)73-47/h10-11,26-44,47-49,56-59,61-68H,12-22H2,1-9H3,(H,69,70)/b23-10-/t26?,27-,28-,29?,30?,31-,32+,33-,34-,35+,36+,37-,38-,39+,40+,41-,42+,43-,44+,47+,48+,49-,51+,52-,53-,54-,55+/m1/s1

Synonyms:

• (2S,3S,4S,5R,6R)-6-[[(4S,6aR,6bS,8R,8aR,9R,10R,14bR)-9-acetoxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(Z)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3,5-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy]tetrahydropyran-2-carboxylic acid
• (3beta,5xi,9xi,16alpha,18xi,21alpha,22alpha)-22-(acetyloxy)-16,24,28-trihydroxy-21-{[(2Z)-2-methylbut-2-enoyl]oxy}olean-12-en-3-yl beta-D-glucopyranosyl-(1->2)-[beta-D-glucopyranosyl-(1->4)]-beta-D-glucopyranosiduronic acid
• 3,5-Epoxypicene, escin deriv.
• Aescin
• Aescusan
• Ba 2672
• Chestnuts extract
• Escigenin, 3-(4-O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-2-O-β-<smallcap>D</smallcap>-xylopyranosyl-β-<smallcap>D</span>-glucopyranuronoside), 3-hydroxy-2-methylbutyrate, acetate
• Escin
• Escusan
• Eskuzan
• Extract of horse chestnut
• Flebostasin Retard
• Horse chestnut extract
• Oleanane, escin deriv.
• Venocin
• β-Escinic acid

Aescin, 98%

CAS: 6805-41-0

It is used and studied as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent.1 It may be used to study its pharmacokinetics, safety and efficacy as a chemosensitizer and modulator of NF- B cell signaling This Thermo Scientific Chemicals brand product was originally part of

Formula: C₅₅H₈₆O₂₄

Purity: 98%

Molecular weight: 1131.26

Ref: 02-J66968

AESCIN FOR LC ASSAY HRS

CAS: 6805-41-0

AESCIN FOR LC ASSAY HRS

Formula: C₅₅H₈₆O₂₄

Color and Shape: Yellowish. Yellow-Brown. Powder. Amorphous.

Molecular weight: 1131.257

Ref: 41-Y0001527

Escin

CAS: 6805-41-0

Escin (Aescin) is biosynthesized from protoaescigenin and barringtogenol, occurring in the seeds of Aesculus.

Formula: C₅₅H₈₆O₂₄

Purity: 88.51%

Color and Shape: White Powder

Molecular weight: 1131.27

Ref: TM-T0278

Aescine

CAS: 6805-41-0

Aescine

Purity: 97%

Molecular weight: 1131.26g/mol

Ref: 54-OR1027696

Escin

CAS: 6805-41-0

Formula: C₅₅H₈₆O₂₄

Purity: ≥ 95.0%

Color and Shape: Off-white, pale yellow or beige powder

Molecular weight: 1131.26

Ref: 7W-GC8310

Escin

CAS: 6805-41-0

Escin

Purity: ≥80%

Molecular weight: 1131.27g/mol

Ref: 54-BUP16068

Aescine

CAS: 6805-41-0

Formula: C₅₅H₈₆O₂₄

Purity: Mixture(Total Aescins), Total saponins>98%Analysis Method

Molecular weight: 1131.27

Ref: BP-BP3711

Escin

CAS: 6805-41-0

Natural glycoside

Purity: ≥ 75.0 % (HPLC)

Color and Shape: Powder

Molecular weight: -

Ref: 5G-89871

Escin (mixture of natural saponins, Technical Grade)

CAS: 6805-41-0

Formula: C₅₅H₈₆O₂₄

Color and Shape: Neat

Molecular weight: 1131.26

Ref: TR-E658790

Aescin

CAS: 6805-41-0

Beta-Aescin (also known as€ beta-escin) is a mixture of saponins produced by the horse chestnut tree, Aesculus hippocastanum, with most published reports relating to the pharmacological properties that it shows. It is reported that beta-aescin is a safe and very tolerable drug in the treatment of post thrombotic syndrome and chronic venous insufficiency. Aescin shows promise in the treatment of arthritis and appears to have potential as an anti-cancer drug. In fact, beta-aescin is active on glioblastoma-initiating cells (GIC), which have the ability to initiate glioblastoma growth. Glioblastoma multiform is the most abundant primary tumor of the human nervous system. Beta-aescin was more efficient in diminishing GIC growth compared to present clinically used drugs.

Formula: C₅₅H₈₅O₂₄

Color and Shape: Powder

Molecular weight: 1,131.26 g/mol

Ref: 3D-OA07948